PhysiologybioRxiv
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
S. S. Madhavan, S. Roa Diaz, S. Peralta…·J. C. Newman
This study identifies β-hydroxybutyrate as a metabolic regulator of protein solubility in aging and Alzheimer's disease, showing it reduces insolubility of pathological proteins like amyloid-β.
DOI 10.1016/j.chembiol.2024.11.001