H. Wilson

Phase-separating pyrenoid proteins form complexes in the dilute phase

The paper demonstrates the existence of protein complexes in the dilute phase of phase-separating systems using an algal pyrenoid reconstitution system and fluorescence correlation spectroscopy.

The P681H mutation in the Spike glycoprotein escapes IFITM restriction and is necessary for type I interferon resistance in the SARS-CoV-2 alpha variant

This paper shows the P681H mutation in the SARS-CoV-2 alpha variant's Spike protein enables resistance to type I interferon and IFITM proteins, enhancing viral entry and transmission.

A nuclear export signal in KHNYN required for its antiviral activity evolved as ZAP emerged in tetrapods

Regulation of KHNYN antiviral activity by the extended di-KH domain and nucleo-cytoplasmic trafficking

This paper identifies the extended di-KH and CUBAN domains in KHNYN as critical for its antiviral activity and interaction with ZAP, showing that the CUBAN domain regulates trafficking and abundance.

The P681H mutation in the Spike glycoprotein confers Type I interferon resistance in the SARS-CoV-2 alpha (B.1.1.7) variant

This study shows the P681H mutation in the SARS-CoV-2 alpha variant's Spike protein confers resistance to Type I interferon, enhancing viral replication by evading innate immune responses.

Probing DNA-protein interactions using single-molecule diffusivity contrast

The paper introduces a method to determine DNA-protein binding states using diffusivity contrast and validates it with PIFE, enabling simultaneous mapping of stoichiometry and binding location.

TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction

This study identifies TRIM25 and ZAP as key factors in type I interferon-mediated inhibition of Ebola virus replication by targeting the viral ribonucleoprotein complex.

Household transmission of SARS-CoV-2 from humans to pets in Washington and Idaho: burden and risk factors

The paper investigates SARS-CoV-2 transmission from humans to pets in households, finding that 21% of dogs and 39% of cats showed clinical signs, with seropositivity and PCR positivity rates of 40% and 5% in dogs, and 43% and 8% in cats.

High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria

Single-molecule diffusometry reveals no catalysis-induced diffusion enhancement of alkaline phosphatase as proposed by FCS experiments

The paper uses single-molecule techniques to show catalysis does not enhance diffusion of alkaline phosphatase, contradicting previous FCS results attributed to substrate-induced dye blinking.

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

This study uses high-throughput phenotyping of knockout mice to identify genetic factors and structural patterns influencing immune variation.

Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion

This study shows that myeloid Trib1 promotes early atherosclerosis by enhancing foam cell formation through increased lipid uptake and OLR1 expression.

KHNYN is essential for ZAP-mediated restriction of HIV-1 containing clustered CpG dinucleotides

The paper identifies KHNYN as a novel ZAP cofactor essential for restricting HIV-1 with clustered CpG dinucleotides.