Author

S. R. Mackinnon

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Biology Disciplines

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Biochemistry· 1

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Basle· 1 shared C. Burer· 1 shared D. S. Froese· 1 shared L. K. M. Blomgren· 1 shared M. Huber· 1 shared T. J. McCorvie· 1 shared W. W. Yue· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Basle

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1 paper

Recent·Most cited

BiochemistrybioRxivAug 2, 2023

Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase

L. K. M. Blomgren, M. Huber, S. R. Mackinnon…·T. J. McCorvie

The paper determines cryo-EM structures of human MTHFR bound to SAM and SAH, revealing how inter-domain transformations mediate allosteric regulation by altering active site accessibility.

DOI 10.1038/s41467-024-47174-y

humancryo-EM

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