M. Huber

Highly-sensitive reporter cell line for detection of interferon types I-III and their neutralization by antibodies

The paper develops a highly sensitive Renilla luciferase-based reporter cell line to detect IFN types I-III and neutralizing antibodies.

Metabolic Reprogramming Driven by Ant2 -Targeting Augments T-Cell Function and Anti-Tumor Immunity

This study shows that Ant2 deficiency enhances T-cell function and anti-tumor immunity by altering mitochondrial metabolism and metabolic reprogramming.

Herbivory can increase plant fitness via reduced interspecific competition. Evidence from models and mesocosms

This study shows herbivory can increase plant fitness by reducing interspecific competition, supported by models and mesocosm experiments.

KIRA6 is an effective and versatile mast cell inhibitor of IgE-mediated activation

This study identifies KIRA6 as a dual inhibitor of LYN and FYN that suppresses IgE-mediated mast cell activation and inflammation.

Full-length structure of the host targeted bacterial effector Bep1 reveals a novel structural domain conserved in FIC effector proteins from Bartonella

The paper determines the crystal structure of Bep1, revealing a novel FIC-OB-BAS(BID) domain arrangement and its role in T4SS translocation.

Assessing rapid adaptation through epigenetic inheritance: a new experimental approach

This paper introduces an experimental approach to assess whether epigenetic inheritance contributes to rapid adaptation through stochastic or deterministic routes in plants.

Sodium chloride in the tumor microenvironment enhances T-cell metabolic fitness and cytotoxicity

This study shows sodium chloride enhances CD8+ T-cell metabolic fitness and cytotoxicity, improving tumor cell killing in vitro and in vivo.

Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase

The paper determines cryo-EM structures of human MTHFR bound to SAM and SAH, revealing how inter-domain transformations mediate allosteric regulation by altering active site accessibility.

Population genomics and epigenomics provide insights into the evolution of facultative asexuality in plants

The paper analyzes population genomes and epigenomes of Spirodela polyrhiza to show low genomic diversity and DNA methylation levels, with natural selection shaping asexual reproduction traits.

SR-BI regulates the synergistic mast cell response by modulating the plasma membrane-associated cholesterol pool

This paper identifies SR-BI as a regulator of mast cell activation by modulating plasma membrane cholesterol, affecting synergistic responses to multiple stimuli.

Transformation of primary murine peritoneal mast cells by constitutive KIT activation as a result of lost Cdkn2a/Arf expression

The paper describes the generation of a transformed murine mast cell line, PMC-306, and identifies the loss of Cdkn2a/Arf as the cause of its immortalization.

Induced responses contribute to rapid plant adaptation to herbivory

This study shows herbivory-induced responses in plants can evolve rapidly and increase resistance to herbivores through experimental evolution.

Natural rubber reduces herbivory and alters the microbiome below ground

This study shows that natural rubber reduces herbivory and alters the root microbiome in a herbivore-dependent manner in Russian dandelion.

Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation

This study identifies an accelerated methionine cycle in immature CD8+ T cells that suppresses their maturation and immune response, showing that inhibiting the cycle promotes maturation and immune recovery.

Effects of sub-lethal single, simultaneous, and sequential abiotic stresses on phenotypic traits of Arabidopsis thaliana

This study examines how sub-lethal abiotic stresses affect 12 phenotypic traits in Arabidopsis thaliana, finding additive and interactive effects across different stress combinations and accessions.

TRAIP regulates DNA double-strand break-induced ATM activation

This study identifies TRAIP as a novel regulator of ATM activation in response to DNA double-strand breaks, showing its role in maintaining ATM downstream targets and DNA repair.

Towards increased shading potential: a combined phenotypic and genetic analysis of rice shoot architecture

Through screening a rice diversity panel for variation in shoot architecture, we identified traits corresponding to plant shading potential and their genetic constituents.

A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

The paper shows that an insect beta-glucosidase metabolizes a dandelion defense compound, reducing its toxicity and altering herbivore feeding preference.

A clonal fresh water plants acquires transgenerational stress resistance under recurring copper excess

This study shows that repeated copper exposure in freshwater plants leads to improved fitness under recurring stress through transgenerational plasticity.

Detection and functional resolution of soluble multimeric immune complexes by a comprehensive FcγR reporter cell panel

This study establishes a comprehensive FcγR reporter cell assay to detect and quantify soluble immune complexes in experimental and clinical settings.

SARS-CoV-2 Variants Reveal Features Critical for Replication in Primary Human Cells

This study identifies SARS-CoV-2 variants with distinct replication abilities in human and non-human cells, highlighting cell-specific replication features.

Capitalizing on paradoxical activation of the MAPK pathway for treatment of Imatinib-resistant mast cell leukemia and chronic myelogenous leukemia

The paper shows that combining low-dose Ponatinib and Trametinib can overcome Imatinib resistance in mast cell leukemia by inhibiting paradoxical MAPK pathway activation.

Small RNA directs symbiosis, virulence, and natural products biosynthesis in entomopathogenic bacteria

This study identifies ArcZ, an Hfq-dependent sRNA, as essential for small molecule production in entomopathogenic bacteria, revealing its broad regulatory role beyond secondary metabolites.

Local Metabolism of Ethanol to Acetic Acid/Acetate in the Central Nucleus of Amygdala Elicits Sympathoexcitatory Responses through Activation of NMDAR in Sprague Dawley Rats

This study shows ethanol metabolism in the CeA to acetate activates NMDAR, causing sympathoexcitation in rats.

Structural basis for selective targeting of Rac subfamily GTPases by a bacterial effector protein

The paper identifies structural mechanisms enabling a bacterial effector to selectively target Rac subfamily GTPases over closely related subfamilies.

Variation in root secondary metabolites is shaped by past climatic conditions

The paper examines how past climatic conditions influence root secondary metabolites in Taraxacum officinale, finding strong associations with climate rather than current environmental factors.

ARP-T1 is a ciliogenesis protein associated with a novel ciliopathy in inherited basal cell cancer, Bazex-Dupre-Christol Syndrome

This study identifies ARP-T1 as a ciliogenesis protein whose mutations cause Bazex-Dupre-Christol Syndrome, linking it to ciliopathy and skin cancer.

Alternative Splicing of MR1 regulates antigen presentation to MAIT cells

This study investigates how alternative splicing of MR1 affects antigen presentation to MAIT cells, finding that only MR1A can activate MAIT cells while MR1B inhibits their activation.

Adapted dandelions increase seed dispersal potential when they are attacked by root herbivores

The paper shows that dandelion populations under high root herbivore pressure increase seed dispersal potential when attacked, but at the cost of reduced germination.

Discovery of the role of a SLOG superfamily biological conflict systems associated protein IodA (YpsA) in oxidative stress protection and cell division inhibition in Gram-positive bacteria

This paper identifies YpsA, a SLOG superfamily protein in Bacillus subtilis, as a regulator of cell division and oxidative stress response, with conserved function in Staphylococcus aureus.