Neutrophils degranulate GAG-containing proteoglycofili, which block Shigella growth and degrade virulence factors
A. Andre, M. V. Barroso, J. Skerniskyte, M. Siegwald, V. Paul, L. Debande, C. Ridley, I. Svahn, S. Rigaud, J.-Y. Tinevez, R. Vives, P. Sansonetti, B. S. Marteyn
This study shows that neutrophil degranulation releases PGF, which inhibit Shigella growth and degrade its virulence factors, and that hyaluronidase treatment disrupts PGF structure and antimicrobial activity.
bioRxiv · Feb 8, 2022 · PreprintImmunology