Author

F. Larrous

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Bourhy· 4 shared F. Lazarini· 2 shared G. Dias de Melo· 2 shared L. Feige· 2 shared L. Kergoat· 2 shared M. Lecuit· 2 shared P.-M. Lledo· 2 shared A. Komarova· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersMicrobiology

H. Bourhy

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A short sequence in the tail of SARS-CoV-2 envelope protein controls accessibility of its PDZ Binding Motif to the cytoplasm.

B. Neitthoffer, F. Alvarez, F. Larrous, C. Caillet-Saguy, S. Etienne-Manneville, B. Boeda

The paper identifies a short sequence in the SARS-CoV-2 envelope protein tail that regulates the accessibility of its PDZ-binding motif to the cytoplasm.

bioRxiv · Aug 29, 2023Cell Biology

Recognition of copy-back defective interfering rabies virus genomes by RIG-I triggers the antiviral response against vaccine strains

w. AOUADI, V. Najburg, R. Legendre, H. Varet, L. Kergoat, F. Tangy, F. Larrous, A. Komarova, H. Bourhy

This study shows that pathogenic RABV strains lack defective interfering genomes, leading to weak antiviral responses, while attenuated vaccine strains release 5cb DI genomes that enhance RIG-I-mediated IFN signaling and antiviral activity.

bioRxiv · Mar 24, 2022 · PreprintMicrobiology

Cell-type specific innate immune responses shape rabies virus tropism

L. Feige, T. Kozaki, G. Dias de Melo, V. Guillemot, F. Larrous, F. Ginhoux, H. Bourhy

This study investigates how cell-type specific innate immune responses influence rabies virus tropism by comparing susceptibility and antiviral responses in different CNS cell types.

bioRxiv · Jul 26, 2021Microbiology

Anti-COVID-19 efficacy of ivermectin in the golden hamster

G. D. de Melo, F. Lazarini, F. Larrous, L. Feige, L. Kergoat, A. Marchio, P. Pineau, M. Lecuit, P.-M. Lledo, J.-P. Changeux, H. Bourhy

This study evaluates ivermectin's efficacy against SARS-CoV-2 in golden hamsters, finding it reduces inflammation and neurological symptoms without affecting viral load.

bioRxiv · Nov 21, 2020Immunology

SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance

R. Robinot, M. Hubert, G. Dias de Melo, F. Lazarini, T. Bruel, N. Smith, S. Levallois, F. Larrous, J. Fernandes, S. Gellenoncourt, S. Rigaud, O. Gorgette, C. Thouvenot, C. Trebeau, G. Dumenil, , L. A. Chakrabarti

This study shows SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance, potentially facilitating viral spread to the deeper lung.

bioRxiv · Oct 6, 2020 · PreprintMicrobiology