Cell BiologybioRxivPreprint
Structural basis for recognition of unfolded proteins by the ER stress sensor ERN1/IRE1α
M. S. Simpson, H. De Luca, S. Cauthorn…·W. I. Lencer
This study identifies a 7-residue motif in unfolded proteins recognized by IRE1LD, revealing how IRE1 detects misfolded proteins to trigger the UPR.
DOI 10.1101/2023.06.20.545791