Author

M. S. Simpson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

H. De Luca· 2 shared M. J. Grey· 2 shared P. Luong· 2 shared W. I. Lencer· 2 shared A. W. Paton· 1 shared D. De Sutter· 1 shared E. Cloots· 1 shared J. C. Paton· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

H. De Luca

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Author profile →

2 papers

Recent·Most cited

Structural basis for recognition of unfolded proteins by the ER stress sensor ERN1/IRE1α

M. S. Simpson, H. De Luca, S. Cauthorn, P. Luong, N. Udeshi, T. Svinkina, S. S. Schmeider, S. A. Carr, M. J. Grey, W. I. Lencer

This study identifies a 7-residue motif in unfolded proteins recognized by IRE1LD, revealing how IRE1 detects misfolded proteins to trigger the UPR.

bioRxiv · Jun 20, 2023 · PreprintCell Biology

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

M. J. Grey, E. Cloots, M. S. Simpson, N. LeDuc, Y. Serebrenik, H. De Luca, D. De Sutter, P. Luong, J. R. Thiagarajah, A. W. Paton, J. C. Paton, M. Seeliger, S. Eyckerman, S. Janssens, W. I. Lencer

This study shows IRE1β suppresses IRE1α signaling during ER stress by blocking its activation and disrupting a feedback loop that regulates IRE1 expression.

bioRxiv · Mar 23, 2019Cell Biology