Author

A. Makriyannis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Assay:electrophysiology· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

K. Vemuri· 2 shared A. I. Basbaum· 1 shared A. Inoue· 1 shared A. S. Powers· 1 shared B. K. Kobilka· 1 shared B. K. Shoichet· 1 shared C. Iliopoulos-Tsoutsouvas· 1 shared C. Normand· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

K. Vemuri

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Large library docking for cannabinoid-1 receptor agonists with reduced side effects

T. A. Tummino, C. Iliopoulos-Tsoutsouvas, J. M. Braz, E. S. O'Brien, R. M. Stein, V. Craik, N. K. Tran, S. Ganapathy, F. Liu, Y. Shiimura, F. Tong, T. C. Ho, D. S. Radchenko, Y. S. Moroz, S. R. Rosado, , B. K. Shoichet

The paper identifies a new cannabinoid-1 receptor agonist with reduced side effects through large library docking and experimental validation.

bioRxiv · Feb 27, 2023 · PreprintPharmacology & Toxicology

Modulation of cannabinoid receptor signaling by endocannabinoids

K. Krishna Kumar, M. J. Robertson, E. Thadhani, H. Wang, C.-M. Suomivuori, A. S. Powers, L. Ji, S. P. Nikas, M. Gerasi, K. Vemuri, R. Dror, A. Inoue, A. Makriyannis, G. Skiniotis, B. K. Kobilka

This study investigates how endocannabinoids modulate CB1 receptor signaling by comparing their activation of Gi1 with synthetic cannabinoids and revealing structural differences in ligand binding.

bioRxiv · Aug 6, 2022 · PreprintBiochemistry

In vitro determination of the CB1 efficacy of illicit synthetic cannabinoids

S. Sachdev, K. Vemuri, S. Banister, M. Longworth, M. Kassiou, M. J. Santiago, A. Makriyannis, M. Connor

This study evaluates the efficacy of 13 synthetic cannabinoids at the CB1 receptor using receptor depletion and operational model fitting, finding most have higher efficacy than Δ9-THC.

bioRxiv · Aug 6, 2018Pharmacology & Toxicology