S. Sarma

Development of MHC Class I Blocking Peptides to Target Metabolic Dysfunction-Associated Steatohepatitis CD8+ T Cell Activation

The paper develops MHC class I blocking peptides to inhibit CD8+ T cell activation in MASH, reducing inflammation and fibrosis.

Design of parallel ????-sheet nanofibrils using Monte-Carlo search, coarse-grained simulations, and experimental testing

The paper designs 7-mer peptides that self-assemble into parallel β-sheets using computational screening, simulations, and experimental validation.

Introgression of a dominant phototropin1 mutant superenhances carotenoids and boosts flavor-related volatiles in genome-edited tomato RIN mutants

This study introduces a tomato cultivar with extended shelf life, improved taste, and flavor by combining genome-edited ripening mutants with a phototropin1 mutant.

Design of 8-mer Peptides that Block Clostridioides difficile Toxin A in Intestinal Cells

The paper designs 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells using a combination of computational and experimental methods.

Seeing the unseen: A trifoliate (MYB117) mutant allele fortifies folate and carotenoids in tomato fruits

A tomato trifoliate allele encoding a truncated MYB117 transcription factor alters cellular homeostasis and fortifies γ-aminobutyric acid, folate, and carotenoids in tomato fruits.

Mutations in Tomato ACC Synthase2 Uncover Its Role in Development beside Fruit Ripening

This study identifies ACS2's role in tomato development beyond fruit ripening by analyzing two contrasting acs2 mutants and their phenotypic and metabolomic differences.

In-silico analysis of SARS-CoV-2 genomes: Insights from SARS encoded non-coding RNAs

This study analyzes SARS-CoV-2 genomes to identify host and viral miRNAs that may regulate pathogenesis, finding more host miRNAs target SARS-CoV-2 than SARS, suggesting milder pathogenesis.

MutS-Homolog2 Silencing Generates Tetraploid Meiocytes In Tomato (Solanum lycopersicum)

This study shows that silencing MSH2 in tomato leads to tetraploid meiocytes and abnormal pollen formation due to disrupted meiosis and ploidy stability.