Golgi organization is a determinant of stem cell function in the small intestine
S. Scharaw, A. Sola Carvajal, I. Belevich, A. T. Webb, S. Das, S. Andersson, N. Pentinmikko, E. J. Villablanca, J. R. Goldenring, E. Jokitalo, R. J. Coffey, P. Katajisto
This study shows that Lgr5+ stem cells in the small intestine adjust their Golgi apparatus orientation to enhance niche signal reception and tissue regeneration, which is impaired with age.
bioRxiv · Mar 23, 2023 · PreprintCell Biology