Cilium proteomics reveals Numb as a positive regulator of the Hedgehog signaling pathway
X. Liu, P. Yam, S. Schlienger, E. Cai, J. Zhang, W.-J. Chen, O. Torres Gutierrez, V. Jimenez Amilburu, V. Ramamurthy, A. Y. Ting, T. C. Branon, M. Cayouette, R. Gen, T. Marks, J. Kong, , X. Ge
This study identifies Numb as a ciliary protein that promotes Hedgehog signaling by facilitating Ptch1 exit from the cilium through endocytic mechanisms.
bioRxiv · Oct 10, 2022Cell Biology