Cell BiologybioRxiv
Cilium proteomics reveals Numb as a positive regulator of the Hedgehog signaling pathway
X. Liu, P. Yam, S. Schlienger…·X. Ge
This study identifies Numb as a ciliary protein that promotes Hedgehog signaling by facilitating Ptch1 exit from the cilium through endocytic mechanisms.
DOI 10.1038/s41467-024-47244-1