Mycobacterium tuberculosis methyltransferase perturbs host epigenetic programming to promote bacterial survival
P. R. Singh, V. Dadireddy, S. Udupa, S. Kalladi, S. Shee, S. Khosla, R. Rajmani, A. Singh, S. Ramakumar, V. Nagaraja
This study shows that Mtb methyltransferase Rv2067c modifies host histone H3K79 methylation, inhibiting apoptosis and enhancing necrosis to promote bacterial survival.
bioRxiv · Feb 24, 2023 · PreprintMicrobiology