M. Das

LCN2 promotes focal adhesion formation and invasion by stimulating Src activation.

This study shows LCN2 promotes invasion by enhancing focal adhesion formation through Src activation, independent of its iron-binding ability.

Curtailed CaSR expression in peripheral blood mononuclear cells is associated with hypertension

The paper investigates reduced CaSR expression in hypertensive models and links it to impaired NO production and altered Ca2+ dynamics.

Bridging DNA contacts allow Dps from E. coli to condense DNA

This study investigates how DNA topology influences the formation of Dps-DNA complexes, showing that DNA supercoils and bridging contacts facilitate nucleation and stabilization of these structures.

Northeast India: Genetic Inconsistency across Ethnicity and Geography

The paper analyzes the genetic structure of Northeast India, finding a complex interplay between language, ethnicity, and geography, with a novel Trans-Himalayan ancestry uniting the region.

A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

This study identifies a mitochondrial quality control mechanism that reverses phagosome maturation arrest caused by Mycobacterium tuberculosis through RAB7 recruitment and lysosomal targeting.

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

Functional loss of rffG and rfbB, encoding dTDP-glucose 4,6-dehydratase, changes colony morphology, cell shape, motility and virulence in Salmonella Typhimurium

This study shows that deleting both rffG and rfbB in Salmonella Typhimurium causes changes in cell shape, motility, and virulence.

Seasonal plasticity and energy efficiency in migratory buntings is an assemblage of alterations in metabolic and gut microbe adaptations.

This study identifies state-specific changes in serum metabolites and gut microbiota of migratory buntings during different life stages, highlighting metabolic and microbial adaptations during migration.

Mechanistic insights into the role of Ca2+-stimulated AMPK in the secretion of cellulases during carbon stress

This study identifies Ca2+-stimulated AMPK as critical for cellulase secretion in Penicillium funiculosum during carbon stress, revealing a signaling pathway involving SNF1-AMPK and SSP1.

In vitro and in vivo evidences propound therapeutic potential of Lipocalin 2 in cervical carcinoma

This study shows that inhibiting LCN2 with a monoclonal antibody reduces cervical cancer cell proliferation, invasion, and tumor growth in vitro and in vivo.

Novel CAF-identifiers via transcriptomic analysis in oral cancer patients

The paper identifies novel CAF markers in oral cancer through transcriptomic analysis to distinguish CAFs from other cell types.

Establishment and Characterization of Three Novel CAF Cell Lines from HNSCC Patients

This study establishes three novel CAF cell lines from HPV-negative HNSCC patients to study tumor-stroma interactions and identify new therapeutic targets.

Comparative efficacy of antiviral strategies targeting different stages of the viral life cycle: A viral quasispecies dynamics study

This study compares antiviral strategies targeting different stages of the viral life cycle using a quasispecies dynamics model, finding varying impacts on viral load and effectiveness in low-immunity individuals.

Moxifloxacin-mediated killing of Mycobacterium tuberculosis involves respiratory downshift, reductive stress, and ROS accumulation

This study identifies moxifloxacin-induced oxidative stress in Mycobacterium tuberculosis as a mechanism of killing, showing that reductive stress and iron contribute to ROS accumulation and drug efficacy.

Gnas ablation in CD11c+ cells prevents high-fat diet-induced obesity by elevating adipose tissue catecholamine levels and thermogenesis

Establishment and characterization of novel autologous pair primary cultures from two Indian non-habitual tongue carcinoma patients

The paper establishes and characterizes novel autologous primary cultures from two Indian non-habitual tongue carcinoma patients to study tumor-stroma interactions.

Substrate preferences, phylogenetic and biochemical properties of proteolytic bacteria present in the digestive tract of Nile tilapia

The paper isolates and characterizes proteolytic bacteria from Nile tilapia gut, identifying their substrate preferences and phylogenetic diversity.

Neuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLC

This study shows SCLC cells mimic neurons to promote brain metastasis by recruiting astrocytes through factors like Reelin and SERPINE1.

Active Cytoskeletal Composites Display Emergent Tunable Contractility and Restructuring

This study combines experiments and modeling to show how actin, tubulin, and myosin composites exhibit tunable contractility and restructuring through their connectivity and motor density.

Comparative immunogenicity of bacterially expressed soluble trimers and nanoparticle displayed influenza hemagglutinin stem immunogens

This study compares the immunogenicity of soluble trimeric influenza stem domain immunogens and nanoparticle-displayed versions, showing similar protection against homologous and heterologous viral challenges.

Redox Nanomedicine Cures Chronic Kidney Disease (CKD) by Mitochondrial Reconditioning

This study demonstrates that a redox nanomedicine, C-Mn3O4 NPs, treats CKD by restoring mitochondrial function and redox balance in animal models.

Redox Buffering Capacity of Nanomaterials as an Index of ROS-based Therapeutics and Toxicity: A Preclinical Animal Study

This study evaluates the redox buffering capacity of nanomaterials to assess their therapeutic potential and toxicity in a preclinical animal model.

Anti-diabetic effects of Holarrhena antidysentrica extracts: Results from a Longitudinal Meta-analysis

This paper performs a longitudinal meta-analysis of HA extracts' glucose-lowering effects in diabetic rodent models, finding seed extracts more potent than leaf extracts or standard drugs.

Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics

This study investigates myosin-driven actin-microtubule networks and finds they exhibit self-organized contractile dynamics distinct from actin-only networks.

A Nanoceutical Agent for Chemoprevention of Bilirubin Encephalopathy

This paper reports on the development and testing of citrate-functionalized Mn3O4 nanoparticles for the prevention of bilirubin encephalopathy in a mouse model of neonatal hyperbilirubinemia.

Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington's Like Disorder in Preclinical Model

This paper demonstrates that a biocompatible nanozyme can reverse Huntington's-like disorder in a preclinical model by mimicking glutathione peroxidase and integrating into the cellular antioxidant cascade.

Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth

This study investigates how neoantigen heterogeneity affects bystander immune inhibition in pancreatic cancer, finding that high neoantigen frequency is needed for effective antitumor response, which can be improved with immune therapy.

Sequence-based Prediction of Metamorphic Behavior in Proteins

This paper introduces a sequence-based computational model to predict metamorphic behavior in proteins using diversity indices derived from secondary structure predictions, achieving a Matthews correlation coefficient of ~0.4.

Diurnal variations in serum metabolites of wintering redheaded buntings.

The paper examines diurnal metabolite variations in redheaded buntings, finding higher daytime lipid and protein catabolites and night-time short chain fatty acids and taurine, suggesting differential energy use during migration.

Varying crosslinking motifs drive the mesoscale mechanics of actin-microtubule composites

This study investigates how different crosslinking motifs affect the mechanical properties of actin-microtubule composites, revealing scale-dependent elastic and viscous behaviors.