Author

V. Nagaraja

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

A. Singh· 3 shared R. K. Jha· 3 shared K. Anand· 2 shared R. S. Rajmani· 2 shared S. Udupa· 2 shared A. Bhaskar· 1 shared A. Jamithireddy· 1 shared A. K. Mohan· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

A. Singh

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mycobacterium tuberculosis methyltransferase perturbs host epigenetic programming to promote bacterial survival

P. R. Singh, V. Dadireddy, S. Udupa, S. Kalladi, S. Shee, S. Khosla, R. Rajmani, A. Singh, S. Ramakumar, V. Nagaraja

This study shows that Mtb methyltransferase Rv2067c modifies host histone H3K79 methylation, inhibiting apoptosis and enhancing necrosis to promote bacterial survival.

bioRxiv · Feb 24, 2023 · PreprintMicrobiology

Mycobacterium tuberculosis SufR Responds to Nitric oxide via its 4Fe-4S cluster and Regulates Fe-S cluster Biogenesis for Persistence in Mice

K. Anand, A. Tripathi, K. Shukla, N. Malhotra, A. Jamithireddy, R. K. Jha, S. N. Chaudhury, R. S. Rajmani, A. Ramesh, V. Nagaraja, B. Gopal, G. Nagaraju, A. S. N. Seshasayee, A. Singh

This paper shows that Mtb's SufR senses NO via its 4Fe-4S cluster, regulates Fe-S cluster biogenesis, and supports persistence in mice.

bioRxiv · Aug 10, 2020 · PreprintMicrobiology

A multifunctional type IA DNA/RNA topoisomerase with RNA hydrolysis and rRNA processing activities from Mycobacterium smegmatis and Mycobacterium tuberculosis

P. Rani, S. M. Kalladi, H. Bansia, S. Rao, R. K. Jha, P. Jain, T. Bhaduri, V. Nagaraja

This study identifies a multifunctional DNA/RNA topoisomerase in mycobacteria that performs RNA hydrolysis and rRNA processing, highlighting its dual catalytic roles in RNA metabolism.

bioRxiv · Jul 13, 2020 · PreprintBiochemistry

Emergence of a novel immune-evasion strategy from an ancestral protein fold in bacteriophage Mu

S. Karambelkar, S. Udupa, V. N. Gowthami, S. G. Ramachandra, G. Swapna, V. Nagaraja

This paper identifies acetyl CoA and iron as essential for the methylcarbamoylation of phage Mu DNA, revealing a novel mechanism involving Fe-S cluster-mediated free radical chemistry.

bioRxiv · Dec 2, 2019Biochemistry

Efficacy of the β-lactam\β-lactamase inhibitor combination is linked to WhiB4 mediated changes in redox physiology of Mycobacterium tuberculosis

S. Mishra, P. Shukla, A. Bhaskar, K. Anand, P. Baloni, R. K. Jha, A. K. Mohan, R. S. Rajmani, V. Nagaraja, N. Chandra, A. Singh

This paper shows that the effectiveness of the β-lactam/β-lactamase inhibitor combination against Mtb depends on WhiB4-regulated redox changes, with higher mycothiol redox potential enhancing drug efficacy.

eLife · May 26, 2017Peer-reviewedMicrobiology