Author

K. Drlica

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Pironti· 2 shared B. Shopsin· 2 shared C. Zhou· 2 shared R. J. Ulrich· 2 shared S. M. Morales· 2 shared V. J. Torres· 2 shared A. DuMont· 1 shared A. I. Perault· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

A. Pironti

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Microbiota and metabolic adaptation shape Staphylococcus aureus virulence and antimicrobial resistance during intestinal colonization

C. Zhou, M. B. Pawline, A. Pironti, S. M. Morales, A. I. Perault, R. J. Ulrich, M. J. Podkowik, A. Lejeune, A. DuMont, F.-X. Stubbe, A. Korman, D. R. Jones, J. Schluter, A. R. Richardson, P. D. Fey, , B. Shopsin

This study shows that gut microbiota depletion allows MRSA to adapt through genetic changes that enhance colonization fitness but reduce antimicrobial resistance and virulence.

bioRxiv · May 11, 2024 · PreprintMicrobiology

Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus

R. J. Ulrich, M. Podkowik, R. Tierce, I. Irnov, G. Putzel, N. Samhadaneh, K. A. Lacey, D. Boff, S. M. Morales, S. Makita, T. K. Karagounis, E. E. Zwack, C. Zhou, R. Kim, K. Drlica, , B. Shopsin

This study identifies a prophage-encoded methyltransferase, pamA, that enhances virulence in CA-MRSA by epigenetically upregulating fnbA, promoting biofilm formation and abscess size.

bioRxiv · Apr 17, 2024 · PreprintMicrobiology

Moxifloxacin-mediated killing of Mycobacterium tuberculosis involves respiratory downshift, reductive stress, and ROS accumulation

S. Shee, S. Singh, A. Tripathi, C. Thakur, A. T. Kumar, M. Das, V. Yadav, S. Kohli, R. S. Rajmani, N. Chandra, H. Chakrapani, K. drlica, A. Singh

This study identifies moxifloxacin-induced oxidative stress in Mycobacterium tuberculosis as a mechanism of killing, showing that reductive stress and iron contribute to ROS accumulation and drug efficacy.

bioRxiv · Apr 4, 2022 · PreprintMicrobiology

Glutamine is required for M1-like polarization in response to Mycobacterium tuberculosis infection

L. Shi, Q. Jiang, Y. Qiu, I. J. Kurland, K. Drlica, S. Subbian, S. Tyagi

This study identifies glutamine as essential for M1-like macrophage polarization during Mycobacterium tuberculosis infection through metabolic reprogramming involving the TCA cycle and biosynthesis of signaling molecules and antimicrobial metabolites.

bioRxiv · Jan 11, 2022 · PreprintImmunology