S. Shichino

The paper tracks CD8+ T-cell clonotypes after three SARS-CoV-2 mRNA vaccinations and finds that clonotypes from earlier shots are replaced by new ones after subsequent boosters.

This study shows that polyclonal expansion of tumor-reactive T cells, not oligoclonal expansion, correlates with antitumor effects in response to anti-PD-L1 and anti-CD4 treatments.

This study shows that the TCR repertoire is highly conserved between bilateral tumors in a mouse model, supporting its use for temporal analysis of antitumor T cell responses.

This study combines an HMGN1 peptide with PD-L1 blockade to expand stem-like CD8+ T cells and enhance antitumor effects in mouse models.

The paper examines ACE2, TMPRSS2, and Furin expression in nasal and olfactory tissues of humans and mice to understand the mechanisms of COVID-19 related anosmia.