H. Abe

The odor of a nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, is detected by specific olfactory sensory neurons of the green spotted puffers.

The study identifies a specific group of olfactory sensory neurons in green spotted puffers that respond to the nontoxic TTX analog TDT, supporting its role as a chemosensory cue for conspecific attraction and prey detection.

CD8+ T-cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by clonal replacement

The paper tracks CD8+ T-cell clonotypes after three SARS-CoV-2 mRNA vaccinations and finds that clonotypes from earlier shots are replaced by new ones after subsequent boosters.

Group A Streptococcus Induces Lysosomal Dysfunction in THP-1 Macrophages

This study shows Group A Streptococcus (GAS) persists in macrophages by inducing lysosomal dysfunction through membrane perforation and blocking acidification.

Clonal spreading of tumor-infiltrating T cells underlies the robust antitumor immune responses

This study shows that polyclonal expansion of tumor-reactive T cells, not oligoclonal expansion, correlates with antitumor effects in response to anti-PD-L1 and anti-CD4 treatments.

Novel orthonairovirus in rodents and shrews, Gabon

The paper identifies a novel orthonairovirus in small mammals from Gabon, which is genetically related to a virus linked to human neural diseases.

Green spotted puffer can detect an almost nontoxic TTX analog odor using crypt olfactory sensory neurons

The paper shows that green spotted puffers are attracted to 5,6,11-trideoxyTTX, an almost nontoxic TTX analog, detected by crypt-type olfactory sensory neurons.

An almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an odorant for the grass puffer

The paper investigates whether grass puffers detect tetrodotoxin (TTX) and finds that they respond to a less toxic TTX analog, 5,6,11-trideoxyTTX, suggesting it may function as an odorant for chemical communication.

Fine-tuning of β-catenin in thymic epithelial cells is required for postnatal T cell development

This study investigates the role of β-catenin in thymic epithelial cells during postnatal T cell development, showing that its expression must be finely tuned to support proper thymus function.

Native cyclase-associated protein and actin from Xenopus laevis oocytes form a 4:4 complex with a tripartite structure

The paper isolates and characterizes a 4:4 XCAP1-actin complex from Xenopus oocytes, revealing a tripartite structure with potential functional implications.