ImmunologybioRxiv
PI3Kδ hyper-activation promotes the development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
A.-K. Stark, A. Chandra, K. Chakraborty…·K. Okkenhaug
This study identifies a PI3Kδ-driven B cell subset in the lungs that worsens Streptococcus pneumoniae infection independently of antibodies, and shows that inhibiting PI3Kδ improves survival.
DOI 10.1038/s41467-018-05674-8