Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns
J. Stevens, E. Culberson, J. Kinder, A. R. Ramiriqui, J. Gray, M. Bonfield, T.-y. Shao, F. Al Gharabieh, L. Peterson, S. Steinmeyer, W. J. Zacharias, G. Pryhuber, O. Paul, S. Sengupta, T. Alenghat, , H. Deshmukh
This study identifies microbiota-derived inosine as a key factor in promoting CD8+ T cell responses against influenza in newborns by reversing epigenetic dysregulation.
bioRxiv · Apr 9, 2024Immunology