Cancer BiologybioRxivPreprint
Inhibiting adenine synthesis attenuates glioblastoma cell stemness and temozolomide resistance
S. X. Singh, R. Yang, K. Roso…·Y. He
This study shows that inhibiting adenine synthesis with L-Alanosine reduces stemness and temozolomide resistance in MTAP-deficient glioblastoma cells by impairing mitochondrial function.
DOI 10.1101/2021.06.21.449341