Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI.
A. N. Kapustin, S. S. Tsakali, M. Whitehead, G. Chennell, M.-Y. Wu, C. Molenaar, A. Kutikhin, Y. Chen, S. Ahmad, L. Bogdanov, M. Sinitsky, K. Rubina, A. Clayton, F. J. Verweij, D. M. Pegtel, , C. M. Shanahan
This paper shows that fibronectin stimulates vascular smooth muscle cells to secrete collagen VI-rich extracellular vesicles that modulate cell adhesion and directionality by forming focal adhesions in the extracellular matrix.
bioRxiv · Aug 17, 2023 · PreprintCell Biology