Z. Feng

Langerhans cells regulate immunity in adulthood by regulating postnatal dermal lymphatic development

This study shows that Langerhans cells regulate postnatal dermal lymphatic development, which in turn controls adult immune responses.

Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.

Genome-guided, field-deployable loop-mediated isothermal amplification (LAMP) assay for specific detection of Dickeya dadantii

This paper develops a field-deployable LAMP assay for specific detection of Dickeya dadantii in plant materials, achieving high sensitivity and specificity with no false positives or negatives.

Cdc13 exhibits dynamic DNA strand exchange in the presence of telomeric DNA

This study shows that Cdc13 can dynamically exchange DNA strands in the presence of telomeric DNA, revealing a mechanism for its movement at telomeres.

Development of alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell derived liver organoids

This study develops a human induced pluripotent stem cell-derived liver organoid model of alcoholic liver disease to evaluate drug treatments and replicate key pathological features.

p24-Tango1 interactions ensure ER-Golgi interface stability and efficient transport

The paper investigates Drosophila p24 proteins and finds that their interaction with Tango1 is essential for maintaining ER-Golgi interface stability and efficient transport.

ATP13A1 engages GET3 to facilitate substrate-specific translocation

The paper shows ATP13A1 uses GET3 to translocate cleaved signal sequences to the ER in a substrate-specific manner, ensuring efficient and accurate protein localization.

Chlamydial protease-like activating factor targets SLC7A11 for degradation to induce ferroptosis and facilitate dissemination.

This study identifies CPAF-mediated degradation of SLC7A11 as a mechanism for Chlamydia-induced ferroptosis, promoting bacterial dissemination and suggesting therapeutic targeting.

Protein tyrosine phosphatase receptor kappa regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

This study identifies PTPRK's role in promoting hepatocyte metabolic reprogramming in obesity by regulating glycolysis and lipogenesis, with potential therapeutic implications for obesity-related liver diseases.

Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4

This study reports the structures and mechanistic insights of PLD3 and PLD4, revealing their exonuclease activity, phosphatase function, and disease relevance.

Distinct functions of EHMT1 and EHMT2 in cancer chemotherapy and immunotherapy

This study shows EHMT1 and EHMT2 have distinct roles in cancer therapy, with EHMT1 affecting DNA replication and alkylating agents, while EHMT2 influences immunotherapy response via STING expression.

Identification of Host Restriction Factors Critical for Recombinant AAV Transduction of Polarized Human Airway Epithelium

This study identifies host restriction factors critical for rAAV2.5T transduction of polarized human airway epithelium, revealing KIAA0319L's role in transduction but not internalization, and WDR63's role in transduction without involvement in internalization or nuclear entry.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

Structural basis of closed groove scrambling by a TMEM16 protein

This study uses cryoEM to visualize lipid interactions at the closed groove of Ca2+-bound nhTMEM16 and identifies structural changes involved in groove opening and lipid scrambling.

Sorcin-STAT3-Serpin E1/CCL5 axis can be the trigger of pancreatic cancer-associated new-onset diabetes

This study identifies a Sorcin-STAT3-Serpin E1/CCL5 signaling axis that drives pancreatic cancer-associated new-onset diabetes by impairing beta-cells and elevating serpin E1 levels in peripheral blood.

Widespread impact of immunoglobulin V gene allelic polymorphisms on antibody reactivity

This study shows that IGV allelic polymorphisms widely affect antibody reactivity by analyzing antibody-antigen structures and experimental data.

A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism

This study uses deep learning to screen FDA-approved drugs and TCM compounds for anti-SARS-CoV-2 activity by targeting cell entry, identifying several effective candidates.

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.

A unique cell division protein critical for the assembly of the bacterial divisome

This study identifies Aeg1 as a new essential cell division protein in Acinetobacter baumannii that recruits FtsN to initiate cell division.

A 3D-printed flow-cell for on-grid purification of electron microscopy samples directly from lysate

This paper introduces a 3D-printed flow-cell device for on-grid affinity purification of cryo-EM samples directly from lysate, aiming to improve sample preparation efficiency.

Multimodal meta-analysis of fecal metagenomes reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer

This study identifies microbial single nucleotide variants (SNVs) as superior biomarkers for early detection of colorectal cancer, outperforming species-level signatures in multiple validation cohorts.

Structural insights into transcription activation mechanism of the global regulator GlnR from actinobacteria

This paper reports the crystal and cryo-EM structures of GlnR-DNA and GlnR-TAC complexes, revealing the transcription activation mechanism of GlnR in actinobacteria.

ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination

This study identifies ZNF251 haploinsufficiency as a mechanism conferring PARP inhibitor resistance in BRCA1-mutated cancer cells through RAD51-mediated homologous recombination.

Alpha-1-antitrypsin binds to the glucocorticoid receptor with biological significance in macrophages

This study identifies AAT binding to the glucocorticoid receptor in macrophages, showing its role in anti-inflammatory and host-defense functions.

Fluorescence visualization of deep-buried hollow organs

This paper develops bright fluorophores and uses heavy water to improve fluorescence imaging of deep-buried hollow organs, achieving better visualization and diagnosis.

Simultaneous Optimization of Excitation Wavelength and Emission Window for Semiconducting Polymer Nanoparticles to Improve Imaging Quality

This study optimizes excitation wavelength and emission window for SPNs to improve imaging quality, showing L1057 NPs achieve superior resolution and signal-to-background ratio in the NIR-IIb window.

Short OGA is targeted to the mitochondria and regulates mitochondrial reactive oxygen species level

This study identifies short-OGA as a mitochondrial enzyme that reduces O-GlcNAcylation and increases mitochondrial reactive oxygen species levels.

Integrative multi-omics landscape of non-structural protein 3 of severe acute respiratory syndrome coronaviruses

This study uses multi-omics analyses to investigate the functions of NSP3 proteins from SARS-CoV and SARS-CoV-2, revealing their roles in RNA metabolism and immune response.

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

Classical swine fever virus NS5A inhibits NF-κB signaling by targeting NEMO

This paper identifies that NS5A of CSFV inhibits NF-κB signaling by degrading NEMO and blocking its k63-linked polyubiquitination.