Author

S.-E. Ong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:drug response / drug discovery· 3 Approach:deep learning· 2 Approach:statistical model· 2

Frequent Co-Authors

D. J. Maly· 4 shared H.-T. Lau· 3 shared D. Baker· 2 shared J. Z. Zhang· 2 shared M. Golkowski· 2 shared A. Lius· 1 shared A. Oberst· 1 shared A. Shoemaker· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersCancer Biology

D. J. Maly

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance

J. Z. Zhang, S.-E. Ong, D. Baker, D. J. Maly

The paper uses single-cell signaling analysis to identify Major Vault Protein (MVP) as a mediator of RasG12C inhibitor resistance by facilitating Ras activation at different cellular compartments.

bioRxiv · Oct 2, 2023Cancer Biology

Cellular RNA interacts with MAVS to promote antiviral signaling

N. S. Gokhale, K. Somfleth, M. G. Thompson, R. K. Sam, D. M. Marciniak, L. H. Chu, M. Park, S. Dvorkin, A. Oberst, S. M. Horner, S.-E. Ong, M. Gale, R. Savan

The paper shows that cellular RNA interacts with MAVS to scaffold signaling proteins and promote antiviral signaling by facilitating IRF3 phosphorylation.

bioRxiv · Sep 25, 2023 · PreprintImmunology

Computationally designed sensors for endogenous Ras activity reveal signaling effectors within oncogenic granules

J. Z. Zhang, W. H. Nguyen, N. Greenwood, J. C. Rose, S.-E. Ong, D. J. Maly, D. Baker

The paper develops computational sensors to measure endogenous Ras activity and identifies SAM68 as an effector enriched in oncogenic granules, showing its role in enhancing Ras activity and potential as a therapeutic target.

bioRxiv · Nov 22, 2022Cell Biology

Multiplexed profiling of kinase interactomes quantifies cellular network plasticity

M. Golkowski, A. Lius, T. S. Sapre, H.-T. Lau, T. Moreno, D. J. Maly, S.-E. Ong

The paper introduces Ki-CCA, a method to map kinase PPIs across cancer cell lines, revealing network plasticity and identifying therapeutic targets.

bioRxiv · Sep 14, 2021 · PreprintBiochemistry

Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugs

M. Golkowski, H.-T. Lau, M. Chan, H. Kenerson, V. N. Vidadala, A. Shoemaker, D. J. Maly, R. S. Yeung, T. S. Gujral, S.-E. Ong

The paper develops a kinome-centric pharmacoproteomics platform to identify signaling pathways and biomarkers predicting cancer drug responses and resistance in hepatocellular carcinoma.

bioRxiv · Nov 20, 2019Cancer Biology

CCDC186 controls dense-core vesicle cargo sorting by exit

J. Cattin-Ortola, I. Topalidou, H.-T. Lau, B. Hummer, C. S. Asensio, S.-E. Ong, M. Ailion

This study identifies CCDC186 as a regulator of DCV cargo sorting by exit, showing its role in retaining mature DCV cargos and removing non-DCV cargos post-TGN.

bioRxiv · Nov 6, 2019 · PreprintCell Biology