M. Chan

Pulmonary Ventilation Analysis Using 1H Ultra-Short Echo Time (UTE) Lung MRI: A Reproducibility Study

This study evaluates methods for quantifying pulmonary ventilation using 1H UTE MRI, finding that cyclic b-spline registration and specific ventilation provide the most reproducible results.

CDK7 is a Novel Therapeutic Vulnerability in Fibrolamellar Carcinoma

This study identifies CDK7 as a therapeutic target in fibrolamellar carcinoma by showing its activation in FLC cells and efficacy of CDK7 inhibitors in patient-derived models.

A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

The paper identifies a generalized binding pocket for small molecule IKs activators at the extracellular interface of KCNQ1 and KCNE1 channel complexes, explaining their mechanism and guiding future drug design.

The rVSV-EBOV vaccine provides limited cross-protection against Sudan virus in guinea pigs

This study shows that the rVSV-EBOV vaccine provides limited cross-protection against Sudan virus in guinea pigs, while the rVSV-SUDV vaccine offers complete protection.

Sphingosine kinases promote Ebola virus infection and can be targeted to inhibit filoviruses, coronaviruses, and arenaviruses using late endocytic trafficking to enter cells

This study shows that sphingosine kinases (SKs) facilitate entry of late-penetrating viruses like Ebola and SARS-CoV-2 by promoting endocytic trafficking, and their inhibition blocks viral entry.

The Effects of N-linked Glycosylation on SLC6 Transporters

This study uses molecular dynamics simulations to investigate how N-linked glycosylation affects the dynamics of four human SLC6 transporters, finding no consistent structural impact but altered extracellular loop dynamics.

An S1 subunit vaccine and combination adjuvant (COVAC-1) elicits robust protection against SARS-CoV-2 challenge in African green monkeys

COVAC-1, an S1 subunit vaccine with adjuvant, protects African green monkeys from SARS-CoV-2 challenge by reducing viral load and pathology in the respiratory tract.

Elevator-type Mechanism of the Cyanobacterial Bicarbonate Transporter

This study uses molecular dynamics simulations to elucidate the conformational dynamics of the cyanobacterial bicarbonate transporter BicA and identify mutations that lower the free energy barrier for transport.

Olverembatinib inhibits SARS-CoV-2-Omicron variant-mediated cytokine release

This paper shows that Olverembatinib inhibits cytokine release caused by the SARS-CoV-2 Omicron variant in human PBMCs, suggesting it as a potential treatment for severe COVID-19.

Machine learning guided design of high affinity ACE2 decoys for SARS-CoV-2 neutralization

The paper uses machine learning to design high-affinity ACE2 decoys for SARS-CoV-2 neutralization, identifying double mutants with binding affinity comparable to a previously known triple mutant.

Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants

This study shows an engineered ACE2 peptide effectively mitigates ARDS and death in mice infected with multiple SARS-CoV-2 variants.

Structural rearrangement of the intracellular gate of the serotonin transporter induced by Thr276 phosphorylation

This study uses molecular dynamics simulations to show that Thr276 phosphorylation reduces free energy barriers for SERT to transition to the inward-facing state, enhancing serotonin transport.

Cell Sex and Sex Hormones Modulate Kidney Glucose and Glutamine Metabolism in Health and Diabetes

This study shows that cell sex and sex hormones influence glucose and glutamine metabolism in kidney cells, with male cells showing increased metabolic stress and female cells showing better redox balance.

Exposure route, sex, and age influence disease outcome in a golden Syrian hamster model of SARS-CoV-2 infection

This study investigates how exposure route, sex, and age affect SARS-CoV-2 pathogenesis in golden Syrian hamsters, finding significant differences in disease outcomes.

Deep Mutagenesis of a Transporter for Uptake of a Non-Native Substrate Identifies Conformationally Dynamic Regions

This study uses deep mutagenesis to identify mutations enhancing APP+ import by SERT, revealing conformational dynamics and mutationally tolerant regions along the permeation pathway.

Transcriptional Feedback Disruption Yields Escape-Resistant Antivirals

This paper develops feedback-circuit disruptors that inhibit viral replication and prevent resistance evolution in herpesviruses.

Prunella vulgaris extract and suramin block SARS-coronavirus 2 virus Spike protein D614 and G614 variants mediated receptor association and virus entry in cell culture system

This study shows that Prunella vulgaris extract and suramin inhibit SARS-CoV-2 Spike protein-mediated virus entry and reduce cytopathic effects in cell cultures.

North American deer mice are susceptible to SARS-CoV-2

This study shows North American deer mice can be infected and transmit SARS-CoV-2, suggesting they may serve as a potential reservoir for the virus.

An aptamer-based magnetic flow cytometer using matched filtering

This paper develops a magnetic flow cytometer using a GMR SV biosensor array and matched filtering to enable reliable point-of-care diagnostics for noncommunicable diseases.

Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugs

The paper develops a kinome-centric pharmacoproteomics platform to identify signaling pathways and biomarkers predicting cancer drug responses and resistance in hepatocellular carcinoma.

Defining variation in pre-human ecosystems can guide conservation: An example from a Caribbean coral reef

This study defines historical variation in Caribbean coral reefs using fossil records to show that most modern reefs are in novel states, while one reef has remained stable for over 760 years.