The tumor-maintaining function of UTX/KDM6A in DNA replication and the PARP1-dependent repair pathway
S.-P. Wang, L.-W. Yeh, J.-W. Chen, J.-Y. Yeh, M.-H. Kao, H.-C. Hong, S. Wu, W.-M. Cheung, T.-Y. Liu, M. A. E. Aberin, E. Paas-Oliveros, A. Escajeda, E. Shih, W.-Y. Tarn, Y.-M. Chang, L.-H. Wang
This paper identifies UTX/KDM6A's role in tumor maintenance through DNA replication and repair pathways, showing that targeting the protein, not just its enzymatic activity, could be a therapeutic strategy.
bioRxiv · May 31, 2024 · PreprintCancer Biology