Author

J.-W. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Organism:C. elegans· 1

Frequent Co-Authors

A. Escajeda· 1 shared A.-t. Xu· 1 shared C. Gao· 1 shared C. Qin· 1 shared C.-l. Yu· 1 shared C.-R. Huang· 1 shared E. Paas-Oliveros· 1 shared E. Shih· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperCancer Biology

A. Escajeda

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The tumor-maintaining function of UTX/KDM6A in DNA replication and the PARP1-dependent repair pathway

S.-P. Wang, L.-W. Yeh, J.-W. Chen, J.-Y. Yeh, M.-H. Kao, H.-C. Hong, S. Wu, W.-M. Cheung, T.-Y. Liu, M. A. E. Aberin, E. Paas-Oliveros, A. Escajeda, E. Shih, W.-Y. Tarn, Y.-M. Chang, L.-H. Wang

This paper identifies UTX/KDM6A's role in tumor maintenance through DNA replication and repair pathways, showing that targeting the protein, not just its enzymatic activity, could be a therapeutic strategy.

bioRxiv · May 31, 2024 · PreprintCancer Biology

Targeting ductal-endothelial crosstalk alleviate pancreatitis

R.-r. Gao, L.-y. Ma, J.-w. Chen, Y.-x. Wang, Y.-y. Li, Z.-y. Zhou, Z.-h. Deng, J. Zhong, Y.-h. Shu, Y. Liu, Q. Chen

This study shows that blocking integrin-5 signaling reduces acute pancreatitis severity by mitigating ductal-endothelial crosstalk disruption.

bioRxiv · Jan 15, 2024 · PreprintCell Biology

Phage transcriptional regulator X (PtrX)-mediated augmentation of toxin production and virulence in Clostridioides difficile strain R20291

J.-J. Gong, I.-H. Huang, S.-W. Su, S.-X. Xie, W.-Y. Liu, C.-R. Huang, Y. P. Hung, S.-R. Wu, P. J. Tsai, W. C. Ko, J.-W. Chen

This study identifies PtrX, a phage transcriptional regulator, as a key factor enhancing toxin production and virulence in C. difficile strain R20291.

bioRxiv · Aug 24, 2023 · PreprintMicrobiology

Mechanism of glucocorticoid receptor activation regulated expression of thrombospondin-1

G.-X. Zhang, Y.-Y. Wang, Y.-Y. Song, W.-Y. Jiang, H.-T. Zhang, J.-W. Chen, K. Murao, W.-P. Sun

This study shows that glucocorticoid receptor activation increases TSP-1 expression through p38 MAPK and AGO-2 phosphorylation, and microRNA-1-3p inhibition in endothelial cells and platelets.

bioRxiv · Apr 13, 2023 · PreprintPathology

Natural selection and neutral mutations through the lens of viruses

J.-M. Chen, G.-H. Li, H.-Y. Gong, M.-H. Sun, Y.-F. Ji, R.-X. Chen, S.-M. Tan, J.-W. Chen

The paper re-evaluates the role of natural selection and neutral mutations in molecular evolution using viral sequences, finding that existing methods underestimate natural selection's influence and proposing a new interpretation of its mechanisms.

bioRxiv · Oct 10, 2022 · PreprintEvolutionary Biology

Swine Promyelocytic Leukemia Isoform II Inhibits Pseudorabies Virus Infection by Suppressing Viral Gene Transcription in PML-NBs

C.-l. Yu, A.-t. Xu, Y. Lang, C. Qin, X. Yuan, W.-h. Feng, M.-d. Wang, C. Gao, J.-w. Chen, R. Zhang, J. Tang

This study identifies sPML-II as the isoform that inhibits PRV infection by suppressing viral gene transcription through its 7b region.

bioRxiv · Mar 23, 2020Immunology