Sabeeha S Merchant

The paper describes engineered algal lipids that mimic the fatty acid profile and regioisomeric structure of human milk fat for infant formula.

The paper quantifies protein abundances and stoichiometries in Chlamydomonas reinhardtii during the cell cycle using the total protein approach.

The paper introduces a 'mono-mix' strategy to improve proteomic analysis of cross-kingdom microbial symbiosis by addressing detection biases in coculture.

This study investigates overflow metabolism in Chromochloris zofingiensis under different nutrient and light conditions using metabolic flux analysis and transcriptomics.

This study presents a diploid genome assembly and genetic toolkit for Auxenochlorella, revealing evolutionary forces like mitotic recombination and loss-of-heterozygosity, and demonstrating its utility for research and bioengineering.

This paper designs a nutrient-replete medium for Chromochloris zofingiensis to support fast growth and high triacylglycerol accumulation by optimizing mineral concentrations based on cellular ionome data.

This study shows Chlamydomonas reinhardtii can rapidly reprogram its photoprotective strategies in response to changes in diurnal light intensity, with LL-acclimated cells recovering faster than HL-acclimated cells.

The paper shows Fe starvation in green algae leads to a second LHCI tetramer associated with PSI, similar to cyanobacteria's isiA antenna ring.

The paper describes a defined growth medium for Auxenochlorella sp. (UTEX 250-A) under mixotrophic conditions with controlled trace metal levels.

The paper identifies leaky ribosomal scanning as the mechanism enabling tunable translation of bicistronic ORFs in green algae through bioinformatic and in vivo analyses.

The paper identifies a mutation in CEHC1, which encodes FBXO3, leading to normoxic expression of HYDA genes in Chlamydomonas reinhardtii by stabilizing CRR1.

The paper analyzes how Chlamydomonas adapts its gene expression and proteomic profiles to different light conditions, revealing constitutive phenotypes that persist through the night.

This study examines how Chlamydomonas cells adjust to Fe-free conditions, showing rapid transcriptomic changes and slower metabolic shifts.

This study identifies distinct roles of CTR1 and CTR2 in Cu import and mobilization in Chlamydomonas, with CTR1 mediating high-affinity uptake and CTR2 facilitating Cu remobilization under Zn deficiency.

This study quantifies carbon transfer in a microbial alga-bacterium interaction, finding limited carbon flow and bacterial vitamin B12 synthesis despite algal lysis.

The paper analyzes two extremophilic algae to understand their iron management strategies, identifying novel iron-uptake proteins and adaptive mechanisms that enable survival in low-iron environments.

The paper presents version 6 of the Chlamydomonas reinhardtii reference genome, improving assembly quality and revealing structural mutations in laboratory strains.

The paper systematically characterizes gene function in a photosynthetic organism by analyzing mutant phenotypes across diverse conditions and linking them to functional pathways.

The paper optimizes a ChIP-Seq framework for histone modification profiling in Chromochloris zofingiensis and identifies H3K4me3 enrichment at transcription start sites.

The paper shows that reducing histone H3-mediated Cu1+ production restores Fe-S cluster deficiencies in yeast, linking chromatin and mitochondrial function to Fe-S cluster homeostasis.

This study uses ChIP-Seq to profile H3K4 methylation across the Chlamydomonas cell cycle, revealing distinct patterns of mono- and trimethylation at gene promoters and their relationship to gene expression.

Single-cell RNA sequencing reveals that heterogeneity in Chlamydomonas bulk cultures is largely driven by diurnal cycle phases.

The paper shows the histone H3-H4 tetramer acts as a copper reductase enzyme, reducing Cu2+ to Cu1+ and affecting cellular processes dependent on reduced copper.