MicrobiologybioRxiv
Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies
Durgadevi Parthasarathy, Karunakar Reddy Pothula, Sneha Ratnapriya…·Alon Herschhorn
This paper shows that some HIV-1 transmitted/founder Envs are incompletely closed, making them sensitive to antibodies targeting open conformations, and highlights the importance of Env conformational flexibility for bnAb neutralization.
DOI 10.1038/s41467-024-51656-4