Author

T. Bonacci

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. Bolhuis· 2 shared M. Emanuele· 2 shared N. G. Brown· 2 shared X. Wang· 2 shared A. Suzuki· 1 shared C. A. Mills· 1 shared C. Hsu· 1 shared D. L. Bolhuis· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

D. Bolhuis

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Author profile →

3 papers

Recent·Most cited

Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41

T. Bonacci, D. Bolhuis, N. Brown, M. Emanuele

This study identifies molecular determinants of USP18's specificity for ISG15 through comparative analysis with its paralog USP41, revealing structural features essential for enzymatic activity.

bioRxiv · May 28, 2024 · PreprintBiochemistry

Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

R. D. Mouery, C. Hsu, T. Bonacci, D. L. Bolhuis, X. Wang, C. A. Mills, E. D. Toomer, O. G. Canterbury, K. C. Robertson, T. B. Branigan, N. G. Brown, L. E. Herring, M. Emanuele

The paper uses proteomics and PLK1 inhibition to identify proteins degraded at G2/M, showing PLK1's role in coordinating proteolysis via SCF ligases and linking AKAP2 to cell cycle control.

bioRxiv · Oct 11, 2023 · PreprintCell Biology

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

J. Kernan, R. C. Martinez-Chacin, X. Wang, R. L. Tiedemann, T. Bonacci, R. Choudhury, D. Bolhuis, J. S. Damrauer, F. Yan, J. S. Harrison, M. B. Major, K. Hoadley, A. Suzuki, S. B. Rothbart, N. G. Brown, M. J. Emanuele

The paper predicts APC/C substrates in silico, identifies chromatin regulators as substrates, and shows their cell cycle-dependent degradation and impact on DNA methylation.

bioRxiv · Apr 9, 2020Cell Biology