F. Yan

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

This study shows that HSCs produce BMP9/10, which regulate KCs and ECs to maintain liver homeostasis, and their deletion leads to fibrosis and iron overload.

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

Discovery and characterization of highly potent and selective covalent inhibitors of SARS-CoV-2 PLpro

This study identifies and characterizes two covalent PLpro inhibitors, HUP0109 and DX-027, as potential treatments for SARS-CoV-2.

The dynamic nature of neurotensin receptor 1 (NTS1) allostery and signaling bias

This study investigates NTS1 allostery and signaling bias using NMR, showing PIP2 enhances transducer complexation through allosteric connections and β-arrestin modulates receptor conformation.

CRISPR/FnCas12a-mediated efficient multiplex and iterative genome editing in bacterial plant pathogens without donor DNA templates

This paper develops a CRISPR/Cas12a-based genome editing method for bacterial plant pathogens without donor DNA, enabling efficient gene knockout and multiplex editing in Xanthomonas oryzae pv. oryzae.

Ligands tune the local and global motions of neurotensin receptor 1 (NTS1): a DFT-guided solution NMR analysis

This study uses NMR and DFT to analyze sub-nanosecond motions of NTS1, showing ligands affect conformational entropy and dynamics.

Structural insights into the modes of relaxin-binding and tethered-agonist activation of RXFP1 and RXFP2

The paper identifies a conserved motif critical for RXFP1 and RXFP2 activation, showing distinct structural roles in receptor activity.

Integrated Multi-Omics Data Reveals the Molecular Subtypes of Prostate Cancer

This study identifies molecular subtypes of prostate cancer using multi-omics data and clustering algorithms, revealing distinct clinical and biological features associated with each subtype.

Multi-omics consensus ensemble refines the classification of muscle-invasive bladder cancer with stratified prognosis, tumour microenvironment and distinct sensitivity to frontline therapies

This paper refines muscle-invasive bladder cancer classification using multi-omics data, identifying four subtypes with distinct prognoses and therapeutic responses.

Emergence of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Co-harbouring a blaNDM-1-carrying Virulent Plasmid and a blaKPC-2-carrying Plasmid in an Egyptian Hospital

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition

This study shows SpRY expands CRISPR editing in rice by recognizing diverse PAMs, enabling efficient genome modification across various loci.

Tumor Immunity Microenvironment-based classifications of bladder cancer for enhancing cancer immunotherapy

This study classifies bladder cancer patients into immune and non-immune groups using NMF and NTP algorithms, finding immune-activated patients respond better to anti-PD-1 therapy.

Antifeedant activities of L-arabinose to caterpillars of the cotton bollworm Helicoverpa armigera (Hübner)

This study investigates L-arabinose's antifeedant effects on cotton bollworm caterpillars, showing it deters feeding, suppresses gustatory responses, and inhibits sucrase activity.

Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine.

This study reprograms human adipocytes into induced multipotent stem cells using PDGF-AB and 5-Azacytidine, showing their ability to regenerate tissues without ectopic growth.

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

The paper predicts APC/C substrates in silico, identifies chromatin regulators as substrates, and shows their cell cycle-dependent degradation and impact on DNA methylation.

Wnt Regulation: Exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex

The paper investigates Wnt signaling by examining Axin-Dishevelled interactions and the recruitment of the SCF E3 ubiquitin ligase to the destruction complex, revealing dynamic roles of Axin and Dishevelled.

Volumetric two-photon imaging in live cells and embryos via axially gradient excitation

This paper introduces a gradient two-photon microscopy technique that enables rapid volumetric imaging with reduced phototoxicity by using two axially gradient excitation beams.

A plant protein NbP3IP induces autophagy and mediates the autophagic degradation of RSV p3 to inhibit viral infection

The paper identifies NbP3IP as a plant protein that induces autophagy and degrades RSV p3, inhibiting viral infection.

HDL-AuNPs-BMS nanoparticle conjugates as molecularly targeted therapy for leukemia

This paper develops HDL-AuNPs-BMS conjugates for leukemia treatment, showing enhanced drug delivery and epigenetic modulation in AML cells and mice.