Author

T. J. Esparza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

D. L. Brody· 2 shared N. P. Martin· 2 shared E. R. Goldman· 1 shared G. P. Anderson· 1 shared H. Bielefeldt-Ohmann· 1 shared M. J. Pazgier· 1 shared R. A. Bowen· 1 shared W. D. Tolbert· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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2 shared papersBiochemistry

D. L. Brody

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Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivNov 10, 2021

Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological and pathological disease in a Syrian hamster model of COVID-19

T. J. Esparza, Y. Chen, N. P. Martin…·D. L. Brody

This study shows that nebulized NIH-CoVnb-112 nanobody reduces weight loss, viral burden, and lung pathology in Syrian hamsters infected with SARS-CoV-2.

DOI 10.1080/19420862.2022.2047144

mouseexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivJul 24, 2020

High Affinity Nanobodies Block SARS-CoV-2 Spike Receptor Binding Domain Interaction with Human Angiotensin Converting Enzyme

T. J. Esparza, N. P. Martin, G. P. Anderson…·D. L. Brody

This study identifies nanobodies that block SARS-CoV-2 spike protein interaction with ACE2, showing high affinity and stability after nebulization.

DOI 10.1038/s41598-020-79036-0

humanprotein structure

𝕏 PostBluesky