PI3K Activation In Neural Stem Cells Drives Tumorigenesis Which Can Be Suppressed By Targeting CREB
P. Daniel, G. Filiz, D. Brown, M. Christie, P. Waring, Y. Zhang, J. Haynes, C. Pouton, D. Flanagan, E. Vincan, T. Johns, K. Montgomery, W. Phillips, T. Mantamadiotis
This study shows that PI3K pathway activation in neural stem cells initiates tumorigenesis, and targeting CREB reduces tumor growth in a mouse model of high-grade glioma.
bioRxiv · May 30, 2017Cancer Biology