M. Christie

The paper reclassifies YAP1-expressing SCLC-Y as SMARCA4-deficient malignancies, showing they lack SCLC features and instead resemble SMARCA4-deficient tumors.

This study uses single-molecule fluorescence imaging to analyze the kinetics of PFO pore formation, revealing that membrane insertion is kinetically controlled.

This study determines the crystal structures of GIGYF1/2 GYF domains interacting with TNRC6 proteins, revealing how they bridge 4EHP to miRNA targets for translational repression.

The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.

The paper models the evolution of pesticide resistance in sea lamprey and finds resistance alleles can fixate within 40-80 years of pesticide use despite long generation times.

This paper develops an intravenous pentamidine formulation using Pluronic micelles to enhance CNS exposure for stage 2 HAT treatment, finding no major neurotoxicity but limited BBB penetration enhancement.

This study shows that PI3K pathway activation in neural stem cells initiates tumorigenesis, and targeting CREB reduces tumor growth in a mouse model of high-grade glioma.