Author

E. Vincan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. M. Tran· 2 shared B. Tran· 2 shared D. Flanagan· 2 shared S. A. Waters· 2 shared S. L. Wong· 2 shared A. J. Thrasher· 1 shared A. K. Amaya· 1 shared A. K. Voss· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

B. M. Tran

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

D. Frank, M. Bergamasco, M. Mlodzianoski, A. Kueh, E. Tsui, C. Hall, G. Kastrappis, A. K. Voss, C. McLean, M. C. Faux, K. Rogers, B. Tran, E. Vincan, D. Komander, G. Dewson, H. Tran

This study identifies Trabid mutations that disrupt APC trafficking and neurite growth by impairing DUB activity or STRIPAK binding, leading to neurodevelopmental defects.

bioRxiv · Jul 17, 2023Cell Biology

Uncovering strain- and age-dependent differences in innate immune response to SARS-CoV-2 infection in nasal epithelia using 10X single-cell sequencing

J. J.-Y. Chang, S. Grimley, B. Tran, G. Deliyannis, C. Tumpach, E. J. Steinig, S. L. Wong, S. A. Waters, T. P. Stinear, M. E. Pitt, D. F. J. Purcell, E. Vincan, L. J. M. Coin

The paper uses single-cell sequencing to compare innate immune responses to SARS-CoV-2 in nasal epithelial cells from adults and adolescents, finding age- and strain-dependent differences.

bioRxiv · Mar 4, 2023 · PreprintImmunology

Human Liver Organoids as a Patient-derived Model for HBV Infection and Cellular Response

C. K. Lim, O. Romeo, A. P. Chilver, B. M. Tran, D. Flanagan, E. N. Kirby, J. Breen, E. Vincan, N. Warner, E. M. McCartney, M. Van der Hoek, A. Ruszkiewicz, E. Tse, M. R. Beard

This paper develops a liver organoid model to study HBV infection and antiviral responses, showing it supports the full HBV lifecycle and can assess drug and immunomodulator effects.

bioRxiv · Oct 20, 2022 · PreprintMicrobiology

Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectors

A. Westhaus, M. Cabanes-Creus, K. L. Dilworth, E. Zhu, D. Salas Gomez, R. G. Navarro, A. K. Amaya, S. Scott, M. Kwiatek, A. L. McCorkindale, T. E. Hayman, S. Frahm, D. P. Perocheau, B. M. Tran, E. Vincan, , L. Lisowski

This study evaluates six AAV vectors in twelve preclinical liver models to identify the most predictive for AAV capsid selection in human hepatocyte transgene delivery.

bioRxiv · Sep 28, 2022 · PreprintBioengineering

PI3K Activation In Neural Stem Cells Drives Tumorigenesis Which Can Be Suppressed By Targeting CREB

P. Daniel, G. Filiz, D. Brown, M. Christie, P. Waring, Y. Zhang, J. Haynes, C. Pouton, D. Flanagan, E. Vincan, T. Johns, K. Montgomery, W. Phillips, T. Mantamadiotis

This study shows that PI3K pathway activation in neural stem cells initiates tumorigenesis, and targeting CREB reduces tumor growth in a mouse model of high-grade glioma.

bioRxiv · May 30, 2017Cancer Biology