Author

T. Kitten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 8 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Organism:bacteria (other)· 4 Research Focus:gene regulatory network inference· 4 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

T. Puccio· 4 shared P. Xu· 3 shared B. Zhu· 2 shared L. Bao· 2 shared V. Anandan· 2 shared Z. Zhu· 2 shared A. C. Schultz· 1 shared A. Ismail· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

T. Puccio

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Experimental evolution of gene essentiality in bacteria

L. Bao, Z. Zhu, A. Ismail, B. Zhu, V. Anandan, M. Whiteley, T. Kitten, P. Xu

The paper generates essential gene deletion mutants in Streptococcus sanguinis and identifies suppressor mutations through experimental evolution, revealing new gene and pathway relationships.

bioRxiv · Jul 16, 2024Evolutionary Biology

A novel infective endocarditis virulence factor related to multiple functions for bacterial survival in blood was discovered in Streptococcus sanguinis

P. Xu, V. Anandan, L. Bao, Z. Zhu, J. Bradley, V.-F. Assi, H. Chavda, T. Kitten

This study identifies SSA_0451 as a novel virulence factor in Streptococcus sanguinis that enhances survival in blood by mitigating oxidative and environmental stress.

bioRxiv · Jul 3, 2024 · PreprintMicrobiology

Glycerol Metabolism Contributes to Competition by Oral Streptococci through Production of Hydrogen Peroxide

Z. A. Taylor, P. Chen, P. Noeparvar, D. N. Pham, A. R. Walker, T. Kitten, L. Zeng

This study shows that glycerol metabolism in oral commensal streptococci produces hydrogen peroxide, enhancing competition against the pathogen Streptococcus mutans.

bioRxiv · Jun 28, 2024Microbiology

Contribution of metal transporters of the ABC, ZIP, and NRAMP families to manganese uptake and infective endocarditis virulence in Streptococcus sanguinis

T. Puccio, K. Kunka, T. Kitten

This study identifies manganese transporters in Streptococcus sanguinis and shows their roles in virulence and serum growth.

bioRxiv · May 28, 2021Microbiology

Manganese transport by Streptococcus sanguinis in acidic conditions and its impact on growth in vitro and in vivo

T. Puccio, A. C. Schultz, C. A. Lizarraga, A. S. Bryant, D. J. Culp, R. Burne, T. Kitten

This study investigates the role of the SsaACB manganese transporter in Streptococcus sanguinis under acidic conditions and its impact on growth and virulence.

bioRxiv · May 28, 2021Microbiology

Time-course analysis of Streptococcus sanguinis after manganese depletion reveals changes in glycolytic, nucleotide, and redox metabolites

T. Puccio, B. B. Misra, T. Kitten

This study uses metabolomics to analyze changes in Streptococcus sanguinis after manganese depletion, identifying shifts in glycolytic, nucleotide, and redox metabolites.

bioRxiv · Aug 30, 2020Microbiology

Manganese depletion leads to multisystem changes in the transcriptome of the opportunistic pathogen Streptococcus sanguinis

T. Puccio, K. S. Kunka, B. Zhu, P. Xu, T. Kitten

This study shows that manganese depletion in Streptococcus sanguinis causes widespread transcriptomic changes, affecting multiple systems and growth, but no single factor fully explains the growth defect.

bioRxiv · Aug 6, 2020Microbiology

A novel sialic acid-binding adhesin present in multiple species contributes to the pathogenesis of infective endocarditis

M. O. Gaytan, A. K. Singh, S. A. Woodiga, S. A. Patel, S.-S. An, A. Vera Ponce de Leon, S. McGrath, A. R. Miller, J. M. Bush, M. van der Linden, V. Magrini, R. K. Wilson, T. Kitten, S. J. King

This study identifies a novel sialic acid-binding adhesin, AsaA, in IE-causing bacteria that contributes to pathogenesis by binding platelets through sialic acid, expanding the known role of sialic acid as a receptor in bacterial-platelet interactions.

bioRxiv · Jul 17, 2020Microbiology

Manganese acquisition is essential for virulence of Enterococcus faecalis

C. Colomer-Winter, A. L. Flores-Mireles, S. P. Baker, K. L. Frank, A. J. Lynch, S. J. Hultgren, T. Kitten, J. A. Lemos

This study identifies and characterizes Mn acquisition systems in E. faecalis, showing their critical role in virulence and demonstrating their potential as antimicrobial targets.

bioRxiv · May 16, 2018Microbiology