L. Bao

Experimental evolution of gene essentiality in bacteria

The paper generates essential gene deletion mutants in Streptococcus sanguinis and identifies suppressor mutations through experimental evolution, revealing new gene and pathway relationships.

A novel infective endocarditis virulence factor related to multiple functions for bacterial survival in blood was discovered in Streptococcus sanguinis

This study identifies SSA_0451 as a novel virulence factor in Streptococcus sanguinis that enhances survival in blood by mitigating oxidative and environmental stress.

Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre

The paper investigates the effects of rRNA modifications in the peptidyl transferase center on ribosome function and growth, finding that combined knockouts cause growth defects and biochemical impairments.

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

22kHz Ultrasonic Vocalizations and Body Freezing May Represent Two Systems of Fear in Rodent Fear Conditioning Paradigms

This study investigates two fear responses in rodents, finding that 22kHz ultrasonic vocalizations reflect subjective fear while body freezing indicates an automatic defensive response.

Cryo-EM of α-tubulin isotype containing microtubules revealed a contracted structure of α4A/β2A microtubules

The paper determines cryo-EM structures of microtubules composed of different α-tubulin isotypes and finds that α4A/β2A microtubules show longitudinal contraction compared to other isotype combinations.

Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response

This study shows that SLC7A5 regulates Paneth cell function, affecting intestinal inflammation and cell proliferation through mTORC1 signaling.

Formation process of the twinning β-form anhydrous guanine platelets in the scallop eyes

This study reports the formation mechanism of twinning β-form anhydrous guanine microplatelets in scallop eyes, revealing an intermediate amorphous phase and a two-step crystallization process.

Pathway and mechanism of tubulin folding mediated by TRiC/CCT conjugated with its ATPase cycle revealed by cryo-EM

This study reveals the pathway and mechanism of TRiC-mediated tubulin folding using cryo-EM structures and XL-MS, showing how tubulin is stabilized during the ATPase cycle.

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9

This study identifies JM03, a crotamiton derivative, as a small molecule that extends C. elegans lifespan and improves stress resistance by inhibiting OSM-9 and activating SKN-1 signaling.

Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.

Calcium-binding protein S100A6 interaction with VEGF receptors integrates signaling and trafficking pathways

This study identifies S100A6 as a calcium-dependent regulator of VEGFR trafficking and signaling, integrating these processes in endothelial cell responses to VEGF-A.

Multiview super-resolution microscopy

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

Norstictic acid is a selective allosteric transcriptional regulator

This study identifies norstictic acid as a selective allosteric inhibitor of Med25-mediated transcriptional interactions, showing its effect in vitro and in a breast cancer model.

Classical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer

This study identifies distinct lineage states in small cell lung cancer driven by c-Myc and L-Myc, showing their unique roles in molecular subtypes and histology.

Small molecules inhibit SARS-COV-2 induced aberrant inflammation and viral replication in mice by targeting S100A8/A9-TLR4 axis

Rapid development of an inactivated vaccine for SARS-CoV-2

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

Protection of Rhesus Macaque from SARS-Coronavirus challenge by recombinant adenovirus vaccine

This study shows a recombinant adenovirus vaccine protects rhesus macaques from SARS-CoV challenge by inducing immune responses and reducing lung damage.

Comprehensive Network Analysis and Experimental Verification of Dedu Safflower's Influence on Ascites Hepatocarcinoma

This study investigates the effect of Dedu Safflower Powder on ascites hepatocarcinoma using H22 mouse models and identifies the miR-23a-DAPK1-PVT1 signal axis as a potential mechanism.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

Loss Of PTEN Promotes Formation Of Signaling-Capable Clathrin-Coated Pits

This study shows PTEN regulates clathrin-coated pit dynamics by modulating PI(3,4,5)P3 levels, promoting short-lived signaling-capable CCPs in cancer cells.