T. Kunieda

A comparative ultrastructure study of the tardigrade Ramazzottius varieornatus in the hydrated state, after desiccation and during the process of rehydration.

This study compares the ultrastructure of Ramazzottius varieornatus during hydration, desiccation, and rehydration, revealing differences in anhydrobiosis mechanisms compared to Hypsibius exemplaris.

Stress-dependent cell stiffening by tardigrade tolerance proteins through reversible formation of cytoskeleton-like filamentous network and gel-transition

This study identifies CAHS proteins as stress-dependent cytoskeletal-like proteins that form reversible filaments and gels to enhance cell stiffness and dehydration resistance in tardigrades.

Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

Brain aging-dependent glioma traits reversible by NAD+/BDNF-mediated neuronal reactivation

This study shows that aging reduces neuronal signaling in gliomas, but NAD+ and BDNF can reverse these effects, improving outcomes in older mice.

Tumor Edge-to-Core Transition Promotes Malignancy in Primary-to-Recurrent Glioblastoma Progression in a PLAGL1/CD109-mediated mechanism

The paper identifies a CD133down/CD109up signature associated with poor prognosis in glioblastoma recurrence and shows PLAGL1 mediates tumor progression through CD109 regulation.