K. Masuda

A pancreatic cancer mouse model with human immunity

This paper introduces a mouse model of metastatic human pancreatic cancer infiltrated by human immune cells to study tumor immune microenvironment and treatment responses.

Genetic basis of lineage-specific evolution of fruit traits in hexaploid persimmon

The paper identifies loci associated with fruit traits in hexaploid persimmon using genome-wide association analysis, finding no overlap with regions under selective sweep.

Ongoing rapid evolution of a post-Y region revealed by chromosome-scale genome assembly of a hexaploid monoecious persimmon (Diospyros kaki)

This study reveals rapid evolution of the post-Y region in a hexaploid persimmon through chromosome-scale genome assembly and comparative analysis with dioecious relatives.

A Checking Model of Obsessive-Compulsive Disorder Based on the Hypothalamic Defensive System Against a Potential Threat

This study shows that activating PeF UCN3 neurons in mice induces OCD-like checking behaviors, supporting a role for potential threats in OCD pathophysiology.

Murine breast cancers disorganize the liver transcriptome in zonated manners

This study uses spatial transcriptomics to show that breast cancers disrupt liver zonation patterns, affecting specific metabolic and immune pathways in a zonated manner.

Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

This study identifies an allosteric cysteine in JAK1 and TYK2, develops inhibitors targeting it, and shows high subtype selectivity with minimal off-target effects.

Prior selfing occur in larger flowers in a mixed mating species with delayed selfing

The study finds that prior selfing occurs more frequently in larger flowers of Commelina communis under higher pollinator availability, contradicting predictions based on pollinator limitation.

Stress-dependent cell stiffening by tardigrade tolerance proteins through reversible formation of cytoskeleton-like filamentous network and gel-transition

This study identifies CAHS proteins as stress-dependent cytoskeletal-like proteins that form reversible filaments and gels to enhance cell stiffness and dehydration resistance in tardigrades.

Genome-wide cis-decoding for expression designing in tomato using cistrome data and explainable deep learning

This study uses cistrome data and explainable deep learning to predict tomato fruit expression patterns from DNA sequences, identifying key regulatory elements involved in ripening.

The functional and phenotypic diversity of single T-cell infiltrates in human colorectal cancer as correlated with clinical outcome

The paper analyzes T-cell infiltration in colorectal cancer, identifying prognostic and non-prognostic T cell subtypes and their clinical implications.

Low temperature transcriptionally modulates natural peel degreening in lemon (Citrus limon L.) fruit independently of endogenous ethylene

The paper investigates how low temperature promotes peel degreening in lemon fruit through gene regulation, independent of ethylene, by analyzing transcriptome changes and physiological responses.

The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells

The paper uses single-cell sequencing to identify non-genetic heterogeneity in serous ovarian cancer by analyzing normal fallopian tube epithelial cells and their subtype signatures.