T. Jiang

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

Fast adaptive super-resolution lattice light-sheet microscopy for rapid, long-term, near-isotropic subcellular imaging

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

A type II secreted subtilase from commensal rhizobacteria disarms the immune elicitor peptide flg22

The paper identifies a type II secreted subtilase from commensal bacteria that cleaves the immune elicitor flg22, suppressing plant immune responses.

Time-lapse Image Super-resolution Neural Network with Reliable Confidence Quantification for Optical Microscopy

This paper introduces a time-lapse image super-resolution neural network with confidence quantification for optical microscopy, improving temporal consistency and reliability.

Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

Stimulation Effects Mapping for Optimizing Coil Placement for Transcranial Magnetic Stimulation

This paper introduces a framework for optimal TMS coil placement without segmentation or meshing, validated across multiple datasets showing consistent results.

Deep Learning-based Optical Aberration Estimation Enables Offline Digital Adaptive Optics and Super-resolution Imaging

This paper introduces SFE-Net and SFT-DFCAN to estimate and correct optical aberrations in live-cell imaging without additional hardware, achieving fast and accurate super-resolution.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

Interleukin-16/STAT6 recruits CBP/p300 to upregulate TIMP-3 and promote atherosclerotic plaque stability

This study shows IL-16 promotes atherosclerotic plaque stability by upregulating TIMP-3 through STAT6 and CBP/p300 recruitment.

Self-supervised denoising for structured illumination microscopy enables long-term super-resolution live-cell imaging

The paper introduces a self-supervised denoising method for structured illumination microscopy that enables high-quality super-resolution imaging with reduced fluorescence.

Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

Homeostatic control of an iron repressor in a GI tract resident

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

Proline catabolism is key to facilitating Candida albicans pathogenicity

This study shows that proline catabolism is essential for Candida albicans pathogenicity, as mutations in proline utilization genes reduce virulence in animal models.

Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

This study identifies a regulatory axis involving acetylation and ubiquitination of Isw1 in Cryptococcus neoformans that controls multidrug resistance.

Structural basis for BIRC6 to balance apoptosis and autophagy

This study reveals the structural basis of BIRC6's role in balancing apoptosis and autophagy by showing its dimeric structure and interactions with Smac/DIABLO, caspase 3, HtrA2, and LC3.

A major population resource of 474,074 participants in UK Biobank to investigate determinants and biomedical consequences of leukocyte telomere length.

The paper reports LTL measurements in 474,074 UK Biobank participants, identifying factors like age, sex, ethnicity, and white cell count associated with LTL variation.

RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinoma

This study identifies RET activation driven by MAB21L4-CacyBP interaction as a driver of squamous cell carcinoma and shows RET inhibition as a potential therapeutic strategy.

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

An atlas of human viruses provides new insights into diversity and tissue tropism of human viruses

The paper curates an atlas of human viruses, revealing increased diversity in infants and factors influencing tissue tropism, while introducing the Human Virus Database.

Molecular mechanisms associated with clustered lesion-induced impairment of 8-oxoG recognition by the human glycosylase OGG1

This study investigates how clustered 8-oxoG lesions affect hOGG1 recognition using molecular dynamics and machine learning, finding that mismatches reduce repair efficiency by altering 8-oxoG structure.

Transcriptome profiling of Candidatus Liberibacter asiaticus in citrus and psyllids

This study profiles the transcriptome of Candidatus Liberibacter asiaticus in citrus and psyllids, identifying gene expression patterns and differentially expressed genes between hosts.

Genome-wide characterization of Salmonella Typhimurium genes required for the fitness under iron restriction

This study identifies genes in Salmonella Typhimurium essential for survival under iron restriction using Tn-seq, revealing both required and beneficial genes under different iron conditions.

How fragile we are. Influence of STimulator of INterferon Genes, STING, variants on pathogen recognition and immune response efficiency

The paper uses molecular simulations and machine learning to analyze STING variants and explains how structural changes affect immune response efficiency.

Revealing the full biosphere structure and versatile metabolic functions in the deepest ocean sediment of the Challenger Deep

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.

Programming large target genomic deletion and concurrent insertion via a prime editing-based method: PEDAR

The paper introduces PEDAR, a prime editing method that deletes and repairs genomic insertions, restoring gene function in a mouse model.

Spatial-temporal targeted and non-targeted surveys to assess microbiological composition of drinking water in Puerto Rico following Hurricane Maria.

This study assessed drinking water microbiome changes in Puerto Rico after Hurricane Maria using targeted and non-targeted microbial analysis, finding no significant deterioration in biological quality.

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

A dynamic view of histone tails interaction with clustered abasic sites in a nucleosome core particle

The paper investigates the structural behavior of clustered abasic sites in a nucleosome core particle using molecular dynamics simulations and identifies key histone residues involved in DNA-protein cross-linking.