Cold sensitivity of the SARS-CoV-2 spike ectodomain
R. J. Edwards, K. Mansouri, V. Stalls, K. Manne, B. Watts, R. Parks, K. Janowska, S. M. C. Gobeil, M. Kopp, D. Li, X. Lu, Z. Mu, M. Deyton, T. Oguin, J. Sprenz, , P. Acharya
The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.
bioRxiv · Jul 12, 2020Biochemistry