Author

M. Deyton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:protein structure prediction· 2 Organism:virus· 2 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

K. Janowska· 5 shared R. J. Edwards· 5 shared R. Parks· 5 shared V. Stalls· 5 shared B. F. Haynes· 4 shared K. Manne· 4 shared K. Mansouri· 4 shared P. Acharya· 4 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersBiochemistry

K. Janowska

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

V. Stalls, J. Lindenberger, S. Gobeil, R. Henderson, R. Parks, M. Barr, M. Deyton, M. Martin, K. Janowska, X. Huang, A. May, M. Speakman, E. Beaudoin, B. Kraft, X. Lu, , P. Acharya

This study determines cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike and compares them to BA.1, revealing structural changes and immune evasion mechanisms.

bioRxiv · Apr 7, 2022Biochemistry

Structural diversity of the SARS-CoV-2 Omicron spike

S. Gobeil, R. Henderson, V. Stalls, K. Janowska, X. Huang, A. May, M. Speakman, E. Beaudoin, K. Manne, D. Li, R. Parks, M. Barr, M. Deyton, M. Martin, K. Mansouri, , P. Acharya

The paper compares cryo-EM structures of SARS-CoV-2 Omicron and Delta spikes to analyze conformational changes affecting immune evasion and transmissibility.

bioRxiv · Jan 25, 2022Biochemistry

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

D. Li, R. J. Edwards, K. Manne, D. R. Martinez, A. Schafer, S. M. Alam, K. Wiehe, X. Lu, R. Parks, L. L. Sutherland, T. H. Oguin, C. McDanal, L. G. Perez, K. Mansouri, S. M. C. Gobeil, , Petzol

This study examines SARS-CoV-2 neutralizing and infection-enhancing antibodies, showing in vitro enhancement does not always lead to in vivo disease enhancement, but can cause increased lung inflammation in monkeys.

bioRxiv · Dec 31, 2020 · PreprintImmunology

Cold sensitivity of the SARS-CoV-2 spike ectodomain

R. J. Edwards, K. Mansouri, V. Stalls, K. Manne, B. Watts, R. Parks, K. Janowska, S. M. C. Gobeil, M. Kopp, D. Li, X. Lu, Z. Mu, M. Deyton, T. Oguin, J. Sprenz, , P. Acharya

The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.

bioRxiv · Jul 12, 2020Biochemistry

A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies

P. Acharya, W. Williams, R. Henderson, K. Janowska, K. Manne, R. Parks, M. Deyton, J. Sprenz, V. Stalls, M. Kopp, K. Mansouri, R. J. Edwards, R. Meyerhoff, T. Oguin, G. Sempowski, , B. F. Haynes

The paper shows that HIV-1 broadly neutralizing antibodies recognize a glycan cluster on the SARS-CoV-2 spike protein, revealing a potential target for vaccine design.

bioRxiv · Jun 30, 2020 · PreprintImmunology