Author

Z. Mu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4 Biochemistry· 3 Cancer Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:protein structure· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. F. Haynes· 6 shared R. Parks· 6 shared K. O. Saunders· 5 shared D. Li· 3 shared K. Wiehe· 3 shared M. Barr· 3 shared P. Acharya· 3 shared R. Henderson· 3 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersBiochemistry

B. F. Haynes

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Mechanism of ozone alleviation of malignant ascites in hepatocellular carcinoma through inhibition of NETs

F. Han, C. M. Mu, K. Bian, Z. Mu, Q. Duan, J. Y. Guo, J. Ma, L. Jin, W. Liu, F. Chen

This study shows ozone reduces malignant ascites in hepatocellular carcinoma by inhibiting NETs through AMPK activation and SR-A mediated phagocytosis of DAMPs.

bioRxiv · Apr 26, 2023Cancer Biology

Structure-based stabilization of SOSIP Env enhances recombinant ectodomain durability and yield

D. Wrapp, Z. Mu, B. Thakur, K. Janowska, O. Ajayi, M. Barr, R. Parks, B. H. Hahn, P. Acharya, K. O. Saunders, B. F. Haynes

This paper introduces a proline-stabilization strategy (2P) to enhance the durability and yield of recombinant HIV-1 Env trimers without altering their antigenic or conformational properties.

bioRxiv · Oct 25, 2022Biochemistry

Protection from Omicron and other VOCs by Bivalent S-Trimer COVID-19 Vaccine

D. Su, X. Li, X. Huang, C. He, C. Zeng, Q. Wang, Z. Mu, W. Qin, D. Ambrosino, G. Siber, R. Clemens, J. G. Liang, P. Liang, N. Jackson, R. Xu

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.

bioRxiv · May 3, 2022 · PreprintImmunology

Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles

Z. Mu, K. Wiehe, K. O. Saunders, R. Henderson, D. W. Cain, R. Parks, D. Martik, K. Mansouri, R. J. Edwards, A. Newman, X. Lu, S.-M. Xia, M. Bonsignori, D. Montefiori, Q. Han, , B. F. Haynes

This study shows that nucleoside-modified mRNA can encode HIV-1 Env trimer nanoparticles that induce bnAb precursor B cell expansion and neutralizing activity in mice.

bioRxiv · Aug 9, 2021 · PreprintImmunology

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

K. O. Saunders, N. Pardi, R. Parks, S. Santra, Z. Mu, L. L. Sutherland, R. Scearce, M. Barr, A. Eaton, G. Hernandez, D. Goodman, M. J. Hogan, I. Tombacz, D. Gordon, R. W. Rountree, , B. F. Haynes

This study compares the immunogenicity of mRNA-LNP vaccines to protein vaccines in nonhuman primates, finding comparable or superior HIV-1 antibody responses.

bioRxiv · Dec 30, 2020Immunology

Mouse and Human Antibodies that Bind HLA-E-Leader Peptide Complexes and Enhance NK Cell Cytotoxicity

D. Li, S. Brackenridge, L. C. Walters, O. Swanson, K. Harlos, D. Rozbesky, D. W. Cain, K. Wiehe, R. M. Scearce, M. Barr, Z. Mu, R. Parks, M. Quastel, R. J. Edwards, Y. Wang, , B. F. Haynes

The paper isolates antibodies that bind HLA-E-Leader peptide complexes and enhance NK cell cytotoxicity in both mice and humans.

bioRxiv · Dec 3, 2020Immunology

Cold sensitivity of the SARS-CoV-2 spike ectodomain

R. J. Edwards, K. Mansouri, V. Stalls, K. Manne, B. Watts, R. Parks, K. Janowska, S. M. C. Gobeil, M. Kopp, D. Li, X. Lu, Z. Mu, M. Deyton, T. Oguin, J. Sprenz, , P. Acharya

The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.

bioRxiv · Jul 12, 2020Biochemistry

Precise exogenous insertion and sequence replacements in poplar by simultaneous HDR overexpression and NHEJ suppression using CRISPR-Cas9

A. Movahedi, H. Wei, X. Zhou, J. C. Fountain, Z.-H. Chen, Z. Mu, W. Sun, J. Zhang, D. Li, B. Guo, R. K. Varshney, L. Yang, Q. Zhuge

This paper improves HDR efficiency for gene knock-in in poplar by combining XRCC4 silencing with CtIP and MRE11 overexpression, achieving higher knock-in rates and fewer InDels.

bioRxiv · Jul 4, 2020Plant Biology

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

R. Henderson, M. Lu, Y. Zhou, Z. Mu, R. Parks, Q. Han, A. L. Hsu, E. Carter, S. C. Blanchard, R. Edwards, K. Wiehe, K. O. Saunders, M. J. Borgnia, A. Bartesaghi, W. Mothes, , S. M. Alam

This study identifies a critical role for W571 in HIV-1 Env allostery by showing mutations disrupting CD4-induced rearrangements and rendering Env insensitive to CD4 binding.

bioRxiv · Nov 2, 2019Biochemistry