Author

T. R. Holman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Holinstat· 2 shared A. Glukhova· 1 shared B. E. Tourdot· 1 shared C. Kalyanaraman· 1 shared D. M. Thal· 1 shared H. Venugopal· 1 shared J. C. Freedman· 1 shared J. I. Mobbs· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

M. Holinstat

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Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivMar 10, 2023

Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors

J. I. Mobbs, K. A. Black, M. Tran…·A. Glukhova

This study determines the cryo-EM structures of human 12-LOX, revealing its oligomeric states, catalytic mechanism, and inhibitor binding, which informs drug development.

DOI 10.1182/blood.2023020441

humancryo-EM

𝕏 PostBluesky

BiochemistrybioRxivMar 25, 2020

Altered specificity of 15-LOX-1 in the biosynthesis of 7S,14S-diHDHA implicates 15-LOX-2 in biosynthesis of resolvin D5

S. C. Perry, C. Kalyanaraman, B. E. Tourdot…·T. R. Holman

This paper identifies that h15-LOX-2 preferentially produces RvD5 from 7S-HDHA with faster kinetics than h15-LOX-1, suggesting a greater role for h15-LOX-2 in biosynthesizing resolvin D5.

DOI 10.1194/jlr.ra120000777

humanproteomics

𝕏 PostBluesky