Author

M. Holinstat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

T. R. Holman· 2 shared A. Beaudin· 1 shared A. Glukhova· 1 shared A. H. Schmaier· 1 shared A. Merkulova· 1 shared A. Pellagatti· 1 shared A. Verma· 1 shared A. Vijay· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBiochemistry

T. R. Holman

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Author profile →

6 papers

Recent·Most cited

Protection of β2GPI Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet Activation

P. P. Kulkarni, R. K. Alluri, M. Godwin, G. L. Forbes, A. Merkulova, A. Vijay, M. Palihati, S. Kundu, Y. J. Shim, A. H. Schmaier, M. Holinstat, S. J. Cameron, K. R. McCrae

This study shows that β2GPI-deficient mice are protected from thrombosis and have reduced PAR3-facilitated platelet activation, suggesting β2GPI enhances PAR3's role in thrombin-induced platelet activation.

Blood · May 1, 2025Peer-reviewedCell Biology

An age-specific platelet differentiation path from hematopoietic stem cells contributes to exacerbated thrombosis

D. Poscablo, A. Worthington, S. Smith-Berdan, B. Manso, R. Adili, T. Cool, R. Reggiardo, S. Dahmen, A. Beaudin, S. W. Boyer, M. Holinstat, C. Forsberg

This paper identifies an age-specific platelet differentiation pathway from hematopoietic stem cells that contributes to thrombosis and platelet hyperreactivity in aging.

bioRxiv · Feb 23, 2024Cell Biology

Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism.

B. Harris, D. K. Singh, B. Truong, M. Rhodes, R. Price, S. Shinton, M. Verma, B. Aylward, S. P. Fahl, S. R. Sprinkle, S. Aminov, M. Wang, Y. Zhang, J. Perrigoue, R. Kessel, , D. L. Wiest

This study shows that reduced RPL22 expression in hematopoietic stem cells promotes leukemia by altering metabolism and increasing lipid synthesis via Lin28b.

bioRxiv · May 31, 2023Cancer Biology

Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors

J. I. Mobbs, K. A. Black, M. Tran, H. Venugopal, T. R. Holman, M. Holinstat, D. M. Thal, A. Glukhova

This study determines the cryo-EM structures of human 12-LOX, revealing its oligomeric states, catalytic mechanism, and inhibitor binding, which informs drug development.

bioRxiv · Mar 10, 2023Biochemistry

Deletion of 12-lipoxygenase normalizes platelet function after storage and transfusion in thrombocytopenic mice

H. Larsen, D. A. Byrne, S. Bailey, M. C. Stolla, M. Holinstat, X. Fu, M. Stolla

This study shows that deleting 12-LOX improves post-transfusion function of stored murine platelets by altering fatty acid and oxylipin profiles.

bioRxiv · Sep 23, 2022 · PreprintPhysiology

Altered specificity of 15-LOX-1 in the biosynthesis of 7S,14S-diHDHA implicates 15-LOX-2 in biosynthesis of resolvin D5

S. C. Perry, C. Kalyanaraman, B. E. Tourdot, W. S. Conrad, O. Akinkugbe, J. C. Freedman, M. Holinstat, M. P. Jacobson, T. R. Holman

This paper identifies that h15-LOX-2 preferentially produces RvD5 from 7S-HDHA with faster kinetics than h15-LOX-1, suggesting a greater role for h15-LOX-2 in biosynthesizing resolvin D5.

bioRxiv · Mar 25, 2020Biochemistry