17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice
S. Ali Mondal, R. Sathiaseelan, S. Mann, M. Kamal, W. Luo, T. Saccon, J. Isola, R. Peeler, T. Li, W. M. Freeman, B. Miller, M. Stout
This study shows that 17-E2 reduces liver fibrosis in male mice by decreasing collagen synthesis and increasing collagen degradation.
bioRxiv · Jun 16, 2022Physiology