W. Luo

Occurrence, risk assessment of antibiotics and antimicrobial resistance in Escherichia coli in typical rivers of Sichuan

This study assesses antibiotic and antimicrobial resistance in Escherichia coli from Sichuan rivers, finding high contamination and resistance rates, with specific antibiotics linked to ecological risk.

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

This study shows that SMAD4 and KRAS mutations influence stromal composition and therapeutic response in pancreatic cancer models.

Developing Bioactive Hydrogels Containing Cell-derived Extracellular Matrix: Implications in Drug and Cell-free Bone and Cartilage Repair

This study develops bioactive hydrogels containing cell-derived extracellular matrix for drug-free and cell-free bone and cartilage repair, showing induction of stem cell differentiation.

Ultrasonic Cigarettes: Chemicals and Cytotoxicity are Similar to Heated-Coil Pod-Style Electronic Cigarettes

This study compares the chemicals, cytotoxicity, and risk of aerosols from ultrasonic cigarettes to heated-coil pod-style e-cigarettes, finding no significant reduction in harm.

USP7 Inhibition Promotes Early Osseointegration in Senile Osteoporotic Mice

This study shows that USP7 inhibition accelerates osseointegration in senile osteoporotic mice by enhancing macrophage efferocytosis and inducing apoptosis in aged BMSCs.

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

Immunities Specific to Both of the M Protein Ectodomain and RBD Synergize to Confer Cross-protection against SARS-CoV-2 Infections

This study identifies conserved M protein peptides that elicit cross-neutralizing antibodies against multiple SARS-CoV-2 variants, including Omicron, when combined with RBD-specific antibodies.

Ets1 and IL17RA cooperate to regulate autoimmune responses as well as skin immunity to Staphylococcus aureus

This study shows that Ets1 and IL17RA deficiencies together worsen autoimmune disease and impair skin immunity to Staphylococcus aureus.

iFlpMosaics enable the multispectral barcoding and high-throughput comparative analysis of mutant and wildtype cells

iFlpMosaics enables multispectral barcoding and high-throughput comparison of mutant and wildtype cells using fluorescent labeling and scRNA-seq.

MerTK mediates the immunologically silent uptake of alpha-synuclein fibrils by human microglia

This study shows MerTK mediates microglial uptake of alpha-synuclein fibrils without triggering inflammation and links MERTK variants to Parkinson's disease.

CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth

This study shows that CXCR2 expression in melanoma progenitor cells drives tumor growth by altering transcriptional programs and immune responses.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

Regulation of interstitial fluid flow along adventitia of vasculature by heartbeat and respiration

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

The role and mechanism of NRF2 in endothelial cells and smooth muscle cells of pulmonary artery

The paper investigates NRF2's role in pulmonary artery endothelial and smooth muscle cells under hypoxia, finding differential regulation and effects on proliferation and migration.

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma

Type 17 Follicular Helper T (Tfh17) Cells are Superior for Memory Maintenance

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice

This study shows that 17-E2 reduces liver fibrosis in male mice by decreasing collagen synthesis and increasing collagen degradation.

Senolytic Treatment Reduces Cell Senescence and Necroptosis in Sod1 Knockout Mice that is Associated with Reduced Inflammation and Hepatocellular Carcinoma

Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity

The paper shows that mouse and human kidneys produce biologically active vasopressin in response to NaCl-induced hypertonicity and water restriction.

Spatiotemporal atlas of the fetal brain depicts cortical developmental gradient in Chinese population

This study constructs a spatiotemporal MRI atlas of fetal brain development in Chinese fetuses, revealing a central-to-peripheral cortical growth gradient and dynamic structural asymmetry.

CLASP2 stabilizes GDP-associated terminal tubulins to prevent microtubule catastrophe

This study identifies CLASP2's mechanism of stabilizing GDP-associated terminal tubulins to prevent microtubule catastrophe.

BOS1 is a positive regulator of wounding induced cell death and plant susceptibility to Botrytis

This study identifies BOS1 as a positive regulator of wounding-induced cell death and plant susceptibility to Botrytis cinerea, showing its role in both fertility and disease response.

Rapid macropinocytic transfer of α-synuclein to lysosomes

This study shows alpha-synuclein fibrils are rapidly internalized via macropinocytosis and directed to lysosomes, with some transferred to neighboring cells.

Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosis

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

The synergistic effect of circRNA methylation promotes pulmonary fibrosis

The paper identifies two circRNAs whose m6A methylation synergistically promotes pulmonary fibrosis by targeting eIF4A3, mediated by METTL3.

In planta genome editing with CRISPR/Cas9 ribonucleoproteins

This study uses CRISPR/Cas9 ribonucleoproteins delivered via particle bombardment to edit the wheat genome, resulting in a 10% reduction in culm length without yield loss.

ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast Cancer

This study identifies ZHX2 as a promoter of HIF1α oncogenic signaling in TNBC, showing its role in cell growth, invasion, and metastasis through interaction with HIF1.

Metabolic characteristics of taste differences under the soil and hydroponic cultures of sweet potato leaves by using non-targeted metabolomics

This study compares the metabolic profiles of sweet potato leaves grown in soil versus hydroponic systems to identify metabolites associated with taste quality differences.

Tracking the Movement of Electronic Cigarette Flavor Chemicals and Nicotine from Refill Fluids to Aerosol, Lungs and Exhale

The paper quantifies flavor chemicals and nicotine in EC refill fluids, measures their transfer to aerosols and exhalation, and identifies two user types based on chemical retention and exhalation patterns.

Injectable hydrogels for sustained co-delivery of subunit vaccines enhance humoral immunity

This paper introduces an injectable hydrogel platform for sustained co-delivery of subunit vaccines, which enhances humoral immunity by improving antigen and adjuvant presentation over time.