T. Senda

This study uses cryo-ET to analyze native, active SARS-CoV-2 virions, revealing a transient open-trimer prefusion state and hidden spike flexibility with implications for vaccine design.

This study presents crystal structures of HIV-1 MA domain bound to IP6, revealing its binding mode and interaction with PIP2, providing insights into virion assembly.

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

This study identifies three distinct effector pathways regulated by Apc in murine intestinal epithelia, each contributing to normal tissue homeostasis and tumorigenesis when disrupted by oncogenic Apc mutations.

This study identifies the TRNVF motif as responsible for PI5P4Kβ's GTP binding and extended specificity to ITP and XTP, showing how its GTP preference allows it to function as a GTP sensor despite low cellular concentrations of ITP and XTP.

This paper reports the biochemical and structural characterization of SOR from Sulfurisphaera tokodaii, presenting high-resolution crystal and cryo-EM structures and analyzing the role of iron and cysteines in catalysis.

This paper determines the structure of the insect steroidogenic Halloween protein Noppera-bo and identifies a conserved residue critical for its function.

This study uses serial femtosecond X-ray crystallography to analyze HIV-1 Gag MA-IP6 microcrystals at ambient temperature, achieving high-resolution diffraction data.