S. Vasudevan

The Green Band: Using Production and Catch to Judge Distortive Pressure on an Ecosystem

The paper introduces the 'Green Band' concept to assess fishing pressure's impact on ecosystem structure using catch and production data across four case studies.

Increased 5-HT2A receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics

This study compares 5-HT2A receptor signalling efficacy and bias between serotonergic psychedelics and non-psychedelics, finding that efficacy, not bias, distinguishes them.

The adoption of a westernized gut microbiome in Indian Immigrants and Indo-Canadians is associated with dietary acculturation

The study compares gut microbiomes of Indians, Indo-Immigrants, Indo-Canadians, and Euro-Canadian controls to assess the impact of dietary acculturation on microbiome composition and IBD risk.

Circadian regulation of human immunodeficiency virus type 1 replication

This study shows HIV-1 replication is regulated by circadian rhythms through interactions between transcription factors BMAL1, REV-ERB, and ROR, with implications for HIV therapy.

NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

The paper uses ACE2-overexpressing airway organoids to show NF-κB inhibitor alpha is upregulated during SARS-CoV-2 infection and its reduced function increases viral infection.

The Transcriptome Architecture of Polyomaviruses

The paper characterizes the transcriptome architecture of polyomaviruses using RNA sequencing data, revealing pervasive wraparound transcription and novel conserved transcripts.

Controlling Staphylococcus aureus by 2-phenol (2-MAMP) in a co-culture moderates the biofilm and virulence of Pseudomonas aeruginosa

This study uses 2-MAMP to target Staphylococcus aureus in co-culture with Pseudomonas aeruginosa, reducing P. aeruginosa virulence factors and improving growth inhibition when combined with antibiotics.

Design of a novel DNA Gyrase B inhibitor with a rhodanine scaffold: in silico and in vitro approaches

The paper designs a novel DNA Gyrase B inhibitor using in silico and in vitro methods, identifying qsl-304 as a promising candidate with antibacterial activity against MRSA.

Mapping cellular subpopulations within triple negative breast cancer tumors provides a tool for cancer sensitization to radiotherapy

This study identifies two subpopulations in irradiated TNBC tumors that expand post-RT and shows that targeting both improves radiotherapy sensitivity.

Meiosis and Kinetochore genes are used by cancer cells as genome destabilizers and transformation catalysts

This study shows that overexpression of meiosis and kinetochore genes increases genomic instability and transformation in cancer cells, particularly in genomically stable cell lines.

Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3 upon binding to protease inhibitors

The paper reports crystal structures of DENV4 NS2B-NS3 constructs with and without protease inhibitors, showing how different linkers affect the enzyme's conformation and activity.

A post-transcriptional program of chemoresistance by AU-rich elements and TTP

This study identifies a post-transcriptional mechanism of chemoresistance in leukemia involving AU-rich elements and TTP regulation.